Evidence map›Paper›PMID 29224058›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

Systematic assessment and characterization of chronic pain in multiple sclerosis patients.

Diana Ferraro, Domenico Plantone, Franca Morselli, Giulia Dallari, Anna M Simone, Francesca Vitetta, Patrizia Sola, Guido Primiano, Viviana Nociti, Matteo Pardini and 2 more

Open access · greenAbstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Combined upper limb and breathing exercise programme for pain management in ambulatory and non-ambulatory multiple sclerosis individuals: part II analyses from feasibility study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  10. Pain in patients with multiple sclerosis.Turkish journal of physical medicine and rehabilitation · 2023
    Article
  11. Article
  12. Article
  13. Article
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  18. A voxel-based lesion symptom mapping analysis of chronic pain in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  19. Italian version of the Starkstein Apathy Scale (SAS-I) and a shortened version (SAS-6) to assess "pure apathy" symptoms: normative study on 392 individuals.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Diana FerraroNeurology Unit, Department of Biomedical Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Domenico PlantoneS.O.C. Neurologia, Ospedale San Biagio, Piazza Vittime dei Lager Nazifascisti n.1, 28845, Domodossola, VB, Italy. domenicoplantone@hotmail.com.ORCID http://orcid.org/0000-0001-6666-7244
Franca MorselliNeurology Unit, Department of Biomedical Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Giulia DallariPsychology Unit, Nuovo Ospedale Civile S. Agostino Estense, Modena, Italy.
Anna M SimoneNeurology Unit, Department of Biomedical Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Francesca VitettaNeurology Unit, Department of Biomedical Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Patrizia SolaNeurology Unit, Department of Biomedical Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Guido PrimianoNeurology Institute, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Viviana NocitiNeurology Institute, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Matteo PardiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genova, Italy.
Massimiliano MirabellaNeurology Institute, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
Catello VollonoNeurology Institute, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
University of Modena and Reggio Emilia · ITUniversità Cattolica del Sacro Cuore · ITAzienda Unita' Sanitaria Locale Di Modena · ITMartin University · USOspedale degli Infermi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is one of the most disabling clinical symptoms in patients with multiple sclerosis (MS). Several studies have already assessed the prevalence of pain in MS patients, reporting variable results, probably due to methodological differences. The aim of this single-centre cross-sectional study was to define the prevalence and characteristics of chronic pain in a population of MS patients using validated tools, and to analyse these data in relation to demographic and clinical features, including disease duration and disability (EDSS and its single functional system scores). Of 397 enrolled patients, 23 were excluded due to a Beck's Depression Inventory Score > 19. In the remaining 374 patients, the overall prevalence of chronic pain was 52.1%, most frequently affecting the lower limbs (36.9%). Neuropathic pain was the most frequent type of chronic pain (89 patients, overall prevalence of 23.7%) and was associated with a sensory functional system involvement. Pain intensity was significantly higher in patients with neuropathic pain as opposed to patients with non-neuropathic pain. Patients with chronic pain and, in particular, patients with neuropathic pain had significantly higher EDSS scores than those without pain. Only 24% of patients with chronic pain and 33% of patients with neuropathic pain were on a specific long-lasting treatment for pain. The present study supports the routine assessment of neuropathic pain in MS patients, especially in those with a sensory functional system involvement, in order to avoid underdiagnosing and undertreating a potentially disabling condition.

Indexed as

AnalgesicsChronic PainCross-Sectional StudiesDisability EvaluationFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple SclerosisNeuralgiaPain ManagementPain MeasurementPrevalencePsychiatric Status Rating ScalesAnalgesicsMultiple sclerosisNeuropathic symptomsPainPain treatment

Identifiers

PMID29224058
OpenAlexW2774420102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.