Evidence map›Paper›PMID 29224045›Full record

ArticleAIDS and behavior2018

Association of Adolescent- and Caregiver-Reported Antiretroviral Therapy Adherence with HIV Viral Load Among Perinatally-infected South African Adolescents.

Kirsty Brittain, Nana Akua Asafu-Agyei, Jacqueline Hoare, Linda-Gail Bekker, Helena Rabie, James Nuttall, Paul Roux, Dan J Stein, Heather J Zar, Landon Myer

Abstract read
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kirsty BrittainDivision of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa. kirsty.brittain@uct.ac.za.ORCID 0000-0003-3940-1242
Nana Akua Asafu-AgyeiDepartment of Paediatrics & Child Health, University of Cape Town, Cape Town, South Africa.
Jacqueline HoareDepartment of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Helena RabieDepartment of Paediatrics & Child Health, Tygerberg Academic Hospital & Stellenbosch University, Cape Town, South Africa.
James NuttallDepartment of Paediatrics & Child Health, University of Cape Town, Cape Town, South Africa.
Paul RouxDepartment of Paediatrics & Child Health, University of Cape Town, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.
Heather J ZarDepartment of Paediatrics & Child Health, University of Cape Town, Cape Town, South Africa.
Landon MyerDivision of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

Funding

Cape Town Adolescent Antiretroviral Cohort (CTAAC)R01HD074051 · NICHD · UNIVERSITY OF CAPE TOWN · PI ZAR, HEATHER JOY · 2012 to 2016
$3.0M
National Institute of Child Health and Human Development R01HD074051NICHD NIH HHS R01 HD074051
6 · The paper itself

Abstract

Accurate measurement of antiretroviral therapy (ART) adherence remains challenging and there are few data assessing the validity of self-reported adherence among perinatally HIV-infected adolescents. We examined adolescent and caregiver reports of adolescent adherence among perinatally-infected adolescents aged 9-14 years in Cape Town, South Africa, and explored factors that may modify associations between reported adherence and elevated viral load (VL). Among 474 adolescents (median age 12.0 years; median duration of ART use 7.5 years), elevated VL and caregiver- and adolescent-report of missed ART doses were common. Elevated VL was particularly prevalent among older, male adolescents. Low-moderate concordance was observed between caregiver and adolescent report. Among adolescents aged ≥ 12 years, caregiver- and adolescent-reported adherence was associated with elevated VL across most items assessed, but few significant associations were observed among adolescents < 12 years of age. Refined adherence measures and tools to identify adolescents who require adherence interventions are needed in this context.

Indexed as

Antiretroviral Therapy, Highly ActiveAdolescentBlack PeopleCaregiversChildCross-Sectional StudiesDrug MonitoringFemaleHIV InfectionsHumansMaleMedication AdherencePain ManagementSelf ReportSerologic TestsSouth AfricaAdherenceAdolescentHIVSelf-reportViral load

Identifiers

PMID29224045
PMCPMC6620475

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.