Evidence map›Paper›PMID 29223976›Full record

ArticleG3 (Bethesda, Md.)2018

Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in

Stephanie E Mohr, Kirstin Rudd, Yanhui Hu, Wei Roc Song, Quentin Gilly, Michael Buckner, Benjamin E Housden, Colleen Kelley, Jonathan Zirin, Rong Tao and 4 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Arsenic toxicity in theFrontiers in toxicology · 2025
    Article
  5. Article
  6. Article
  7. Frontiers in cell and developmental biology · 2020
    Article
  8. Generating and working with Drosophila cell cultures: Current challenges and opportunities.Wiley interdisciplinary reviews. Developmental biology · 2019
    Review
  9. Review
  10. Review
  11. Biogenesis of zinc storage granules inThe Journal of experimental biology · 2018
    Article
  12. Copper and Zinc Homeostasis: Lessons fromFrontiers in genetics · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Stephanie E MohrDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115 stephanie_mohr@hms.harvard.edu.ORCID 0000-0001-9639-7708
Kirstin RuddDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Yanhui HuDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0003-1494-1402
Wei Roc SongDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0002-7007-5281
Quentin GillyDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Michael BucknerDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Benjamin E HousdenDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0001-9134-4279
Colleen KelleyDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Jonathan ZirinDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Rong TaoDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Gabriel AmadorDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Katarzyna SierzputowskaDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0002-5445-0264
Aram ComjeanDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.
Norbert PerrimonDrosophila RNAi Screening Center, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0001-7542-472X
Harvard University · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
New collections of dsRNAs and overexpression miRNA constructs to supplement RNAiR01GM067761 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI PERRIMON, NORBERT · 2003 to 2019
$15.5M
Effects of environmental stressors on mitochondrial-cellular cross-talkR21ES025615 · NIEHS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2015 to 2016
$453k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA006516NIEHS NIH HHS R21 ES025615NIGMS NIH HHS R01 GM067761
6 · The paper itself

Abstract

Cells require some metals, such as zinc and manganese, but excess levels of these metals can be toxic. As a result, cells have evolved complex mechanisms for maintaining metal homeostasis and surviving metal intoxication. Here, we present the results of a large-scale functional genomic screen in

Indexed as

AnimalsCell LineDrosophila melanogasterGene Expression ProfilingGene Expression RegulationGenomicsHomeostasisMetalsRNA InterferenceZincMetalsZincABC transportersglutathionehigh-throughput screenmetal detoxificationmetal homeostasis

Identifiers

PMID29223976
PMCPMC5919732
OpenAlexW2951975589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.