ArticleGenetics2018
Keeping Pace with the Red Queen: Identifying the Genetic Basis of Susceptibility to Infectious Disease.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes arising during coevolutionary dynamics.bioRxiv : the preprint server for biology · 2024Article
- Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Molecular biology and evolution · 2024Article
- Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes arising during coevolutionary dynamics.Virus evolution · 2024Article
- Human and pathogen genotype-by-genotype interactions in the light of coevolution theory.PLoS genetics · 2023Review
- Negotiating mutualism: A locus for exploitation by rhizobia has a broad effect size distribution and context-dependent effects on legume hosts.Journal of evolutionary biology · 2022Article
- Coevolutionary theory of hosts and parasites.Journal of evolutionary biology · 2022Review
- Challenges and Opportunities in Understanding Genetics of Fungal Diseases: Towards a Functional Genomics Approach.Infection and immunity · 2021Review
- Tackling microbial threats in agriculture with integrative imaging and computational approaches.Computational and structural biotechnology journal · 2021Review
- Inference of coevolutionary dynamics and parameters from host and parasite polymorphism data of repeated experiments.PLoS computational biology · 2020Article
- Genomics of sorghum local adaptation to a parasitic plant.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Open questions: what are the genes underlying antagonistic coevolution?BMC biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies are widely used to identify "disease genes" conferring resistance/susceptibility to infectious diseases. Using a combination of mathematical models and simulations, we demonstrate that genetic interactions between hosts and parasites [genotype-by-genotype (G × G) interactions] can drastically affect the results of these association scans and hamper our ability to detect genetic variation in susceptibility. When hosts and parasites coevolve, these G × G interactions often make genome-wide association studies unrepeatable over time or across host populations. Reanalyzing previously published data on
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.