ArticleInternational journal for parasitology. Drugs and drug resistance2018
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.
Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 91 citations in OpenAlex.
- Invertebrate Automated Phenotyping Platform (INVAPP): An Automated High-Throughput System with Applications in Understanding and Combating Human Diseases.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture's COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility.BMC research notes · 2025Article
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites.ACS infectious diseases · 2025Article
- An automated, high-resolution phenotypic assay for adult Brugia malayi and microfilaria.Scientific reports · 2024Article
- A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity.Parasites & vectors · 2024Article
- Metal copper and silver revealed potent antimicrobial activity for treatingAmerican journal of translational research · 2024Article
- Human wild-type and D76N βFASEB bioAdvances · 2023Article
- A drug repurposing screen for whipworms informed by comparative genomics.PLoS neglected tropical diseases · 2023Article
- Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics.Parasites & vectors · 2023Article
- wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms.PLoS neglected tropical diseases · 2022Article
- Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Anthelmintic Effect ofMolecules (Basel, Switzerland) · 2022Article
- Meta-Analysis ofFrontiers in microbiology · 2022Article
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- Thermal proteome profiling revealsFrontiers in pharmacology · 2022Article
- Image recognition based on deep learning inComputational and structural biotechnology journal · 2022Article
- Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral VectorMolecules (Basel, Switzerland) · 2021Article
- Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans.International journal for parasitology. Drugs and drug resistance · 2021Article
- Heartworm disease - Overview, intervention, and industry perspective.International journal for parasitology. Drugs and drug resistance · 2021Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms. We have validated its utility by determining the efficacy of a panel of known anthelmintics against model and parasitic nematodes: Caenorhabditis elegans, Haemonchus contortus, Teladorsagia circumcincta, and Trichuris muris. We then applied the system to screen the Pathogen Box chemical library in a blinded fashion and identified compounds already known to have anthelmintic or anti-parasitic activity, including tolfenpyrad, auranofin, and mebendazole; and 14 compounds previously undescribed as anthelmintics, including benzoxaborole and isoxazole chemotypes. This system offers an effective, high-throughput system for the discovery of novel anthelmintics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.