Evidence map›Paper›PMID 29222929›Full record

ArticleClinical transplantation2018

HIV+ deceased donor referrals: A national survey of organ procurement organizations.

Ayla Cash, Xun Luo, Eric K H Chow, Mary Grace Bowring, Ashton A Shaffer, Brianna Doby, Corey E Wickliffe, Charles Alexander, Deborah McRann, Aaron A R Tobian and 2 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  4. Review
  5. A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  6. Review
  7. Donor evaluation in the era of HIV-positive organ transplantation: The importance of the infectious diseases specialist.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  8. Review
  9. Review
  10. Organs from deceased donors with false-positive HIV screening tests: An unexpected benefit of the HOPE act.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayla CashDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6622-5075
Xun LuoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric K H ChowDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mary Grace BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7299-7730
Ashton A ShafferDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0150-4043
Brianna DobyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Corey E WickliffeDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles AlexanderLiving Legacy Foundation, Baltimore, MD, USA.
Deborah McRannLiving Legacy Foundation, Baltimore, MD, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
HOPE in Action: HIV-to-HIV Solid Organ Transplantation in the USR34AI123023 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2016 to 2016
$243k
Understanding the Impact of HIV on Survival in End-Stage Liver DiseaseF30DK116658 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHAFFER, ASHTON A · 2017 to 2019
$149k
NCI NIH HHS K23 CA177321NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI120938NIAID NIH HHS R34 AI123023NIAID NIH HHS U01 AI134591NIDDK NIH HHS F30 DK116658NIDDK NIH HHS K24 DK101828NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

backgroundHIV-infected (HIV+) donor organs can be transplanted into HIV+ recipients under the HIV Organ Policy Equity (HOPE) Act. Quantifying HIV+ donor referrals received by organ procurement organizations (OPOs) is critical for HOPE Act implementation.

methodsWe surveyed the 58 USA OPOs regarding HIV+ referral records and newly discovered HIV+ donors. Using data from OPOs that provided exact records and CDC HIV prevalence data, we projected a national estimate of HIV+ referrals.

resultsFifty-five (95%) OPOs reported HIV+ referrals ranging from 0 to 276 and newly discovered HIV+ cases ranging from 0 to 10 annually. Six OPOs in areas of high HIV prevalence reported more than 100 HIV+ donor referrals. Twenty-seven (47%) OPOs provided exact HIV+ referral records and 28 (51%) OPOs provided exact records of discovered HIV+ cases, totaling 1450 HIV+ referrals and 39 discovered HIV+ donors in the prior year. These OPOs represented 67% and 59% of prevalent HIV cases in the USA; thus, we estimated 2164 HIV+ referrals and 66 discovered HIV+ cases nationally per year.

conclusionsOPOs reported a high volume of HIV+ referrals annually, of which a subset will be medically eligible for donation. Particularly in areas of high HIV prevalence, OPOs require ongoing support to implement the HOPE Act.

Indexed as

Donor SelectionReferral and ConsultationFollow-Up StudiesHIVHIV InfectionsHumansOrgan TransplantationPrognosisTissue and Organ ProcurementTissue Donorsdeceased donorsHIVorgan transplantationpublic health

Identifiers

PMID29222929
PMCPMC5803374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.