Evidence map›Paper›PMID 29222746›Full record

ArticleArchives of toxicology2018

Cadmium favors F-actin depolymerization in rat renal mesangial cells by site-specific, disulfide-based dimerization of the CAP1 protein.

Ying Liu, Weiqun Xiao, Manasi Shinde, Jeffrey Field, Douglas M Templeton

Abstract read
In one paragraph

Article in Archives of toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ying LiuLaboratory Medicine and Pathobiology 1 King's College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Weiqun XiaoLaboratory Medicine and Pathobiology 1 King's College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Manasi ShindeDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jeffrey FieldDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Douglas M TempletonLaboratory Medicine and Pathobiology 1 King's College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada. doug.templeton@utoronto.ca.ORCID http://orcid.org/0000-0003-0693-662X
University of Toronto · CATranslational Therapeutics (United States) · US

Funding

The Role of CAP2 In Sex-Related Myocardial FunctionR01HL134923 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FIELD, JEFFREY M · 2017 to 2020
$1.6M
Steer and trees summer research programsR25ES021649 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI FIELD, JEFFREY M · 2013 to 2022
$830k
Summer Mentorship in Environmental Health Sciences for High School and UndergraduR25ES016146 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI FIELD, JEFFREY M · 2008 to 2012
$311k
Natural Sciences and Engineering Research Council of Canada 418208NHLBI NIH HHS R01 HL134923NIEHS NIH HHS R25 ES016146NIEHS NIH HHS R25 ES021649
6 · The paper itself

Abstract

Cadmium is a toxic metal that produces oxidative stress and has been shown to disrupt the actin cytoskeleton in rat renal mesangial cells (RMC). In a survey of proteins that might undergo Cd

Indexed as

Actin CytoskeletonActin Depolymerizing FactorsActinsAnimalsCadmiumCells, CulturedCysteineCytoskeletal ProteinsDisulfidesMesangial CellsMutationOxidative StressPolymerizationProtein MultimerizationRatsActin Depolymerizing FactorsActinsCadmiumCap1 protein, ratCysteineCytoskeletal ProteinsDisulfidesActin filamentsCadmiumCAP1 proteinCofilinMesangial cell

Identifiers

PMID29222746
PMCPMC6925060
OpenAlexW2772203040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.