ReviewJournal of biomechanical engineering2018
Elastic Fibers and Large Artery Mechanics in Animal Models of Development and Disease.
Review in Journal of biomechanical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Mechanics and mechanobiology of arterial development.Biomechanics and modeling in mechanobiology · 2026Review
- Sexual dimorphism in the downregulation of extracellular matrix genes contributes to aortic stiffness in female mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- Vascular Extracellular Matrix in Atherosclerosis.International journal of molecular sciences · 2024Review
- Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries.Journal of functional biomaterials · 2024Article
- Mechanical Properties and Functions of Elastin: An Overview.Biomolecules · 2023Review
- Biomechanical Properties of the Aortic Wall: Changes during Vascular Calcification.Biomedicines · 2023Article
- Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms.Cells · 2022Review
- Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies.International journal of molecular sciences · 2022Review
- Decellularization of Porcine Carotid Arteries: From the Vessel to the High-Quality Scaffold in Five Hours.Frontiers in bioengineering and biotechnology · 2022Article
- Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling.International journal of molecular sciences · 2021Review
- Pentagalloyl glucose (PGG) partially prevents arterial mechanical changes due to elastin degradation.Experimental mechanics · 2021Article
- Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- How to Measure Arterial Stiffness in Humans.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Venous Mechanical Properties After Arteriovenous Fistulae in Mice.The Journal of surgical research · 2020Article
- Reduced embryonic blood flow impacts extracellular matrix deposition in the maturing aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Development of a closed circulatory system requires that large arteries adapt to the mechanical demands of high, pulsatile pressure. Elastin and collagen uniquely address these design criteria in the low and high stress regimes, resulting in a nonlinear mechanical response. Elastin is the core component of elastic fibers, which provide the artery wall with energy storage and recoil. The integrity of the elastic fiber network is affected by component insufficiency or disorganization, leading to an array of vascular pathologies and compromised mechanical behavior. In this review, we discuss how elastic fibers are formed and how they adapt in development and disease. We discuss elastic fiber contributions to arterial mechanical behavior and remodeling. We primarily present data from mouse models with elastic fiber deficiencies, but suggest that alternate small animal models may have unique experimental advantages and the potential to provide new insights. Advanced ultrastructural and biomechanical data are constantly being used to update computational models of arterial mechanics. We discuss the progression from early phenomenological models to microstructurally motivated strain energy functions for both collagen and elastic fiber networks. Although many current models individually account for arterial adaptation, complex geometries, and fluid-solid interactions (FSIs), future models will need to include an even greater number of factors and interactions in the complex system. Among these factors, we identify the need to revisit the role of time dependence and axial growth and remodeling in large artery mechanics, especially in cardiovascular diseases that affect the mechanical integrity of the elastic fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.