Evidence map›Paper›PMID 29222499›Full record

ArticleNature communications2017

Crystal structure of an RNA-cleaving DNAzyme.

Hehua Liu, Xiang Yu, Yiqing Chen, Jing Zhang, Baixing Wu, Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Chemically Evolved XNAzyme Platforms for Effective In Vivo Gene Regulation.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Programmable DNAzyme nanocatalysts for tumor immunometabolic modulation.Journal of Zhejiang University. Science. B · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Click DNA ligation with deoxyribozyme.Nucleic acids research · 2025
    Article
  12. Article
  13. Article
  14. Sequence-Dependent Acylation of Peptide Lysine Residues by DNAzymes.Chembiochem : a European journal of chemical biology · 2024
    Article
  15. Article
  16. The dynamic world of the 8-17 DNAzyme.Nature communications · 2024
    Article
  17. The Programmable Catalytic Core of 8-17 DNAzymes.Molecules (Basel, Switzerland) · 2024
    Article
  18. Article
  19. DNAzyme-Catalyzed Site-Specific N-Acylation of DNA Oligonucleotide Nucleobases.Angewandte Chemie (International ed. in English) · 2024
    Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hehua LiuState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Xiang YuState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Yiqing ChenState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Jing ZhangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Baixing WuState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China.ORCID http://orcid.org/0000-0003-2502-9785
Lina ZhengState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Phensinee HaruehanroengraDepartment of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA.
Rui WangDepartment of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA.
Suhua LiState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Jinzhong LinState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Jixi LiState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Jia ShengDepartment of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, NY, 12222, USA.
Zhen HuangDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA. huang@gsu.edu.
Jinbiao MaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China. majb@fudan.edu.cn.ORCID http://orcid.org/0000-0002-0232-1786
Jianhua GanState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China. ganjhh@fudan.edu.cn.

Funding

Selenium-Derivatized RNAs and DNAs for High-Throughput Protein/Nucleic Acid CrystR01GM095881 · NIGMS · GEORGIA STATE UNIVERSITY · PI HUANG, ZHEN · 2012 to 2016
$1.4M
Selenium-derivatized New Reagents for Nucleic Acid X-ray CrystallographyR42ES026935 · NIEHS · SENA RESEARCH, INC. · PI HUANG, ZHEN · 2015 to 2016
$1.1M
NIEHS NIH HHS R42 ES026935NIGMS NIH HHS R01 GM095881
6 · The paper itself

Abstract

In addition to storage of genetic information, DNA can also catalyze various reactions. RNA-cleaving DNAzymes are the catalytic DNAs discovered the earliest, and they can cleave RNAs in a sequence-specific manner. Owing to their great potential in medical therapeutics, virus control, and gene silencing for disease treatments, RNA-cleaving DNAzymes have been extensively studied; however, the mechanistic understandings of their substrate recognition and catalysis remain elusive. Here, we report three catalytic form 8-17 DNAzyme crystal structures. 8-17 DNAzyme adopts a V-shape fold, and the Pb

Indexed as

Catalytic DomainRNA CleavageCatalysisCrystallography, X-RayDNA, CatalyticEnzyme AssaysKineticsLeadModels, MolecularNucleic Acid ConformationRNADNA, CatalyticLeadRNA

Identifiers

PMID29222499
PMCPMC5722873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.