ArticleScientific reports2017
A translational model to determine rodent's age from human foetal age.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Qualitative review on N-methyl-D-aspartate receptor expression in rat spinal cord during the postnatal development: Implications for central sensitization and pain.Developmental neurobiology · 2020Pooled it
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- Short- and long-term effects of single neonatal exposure to propofol anesthesia on cognitive function.The Journal of international medical research · 2025Article
- Repetitive neonatal pain increases spinal cord DNA methylation of the µ-opioid receptor.Pediatric research · 2025Article
- Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure.Cells · 2024Article
- Finding a window for gene therapy for hereditary deafness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Single-cell transcriptomic landscape of the developing human spinal cord.Nature neuroscience · 2023Article
- Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract.Journal of radiation research · 2023Review
- Article
- Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia.Stem cell reviews and reports · 2022Review
- TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols.Environmental health perspectives · 2020Article
- Sensorimotor developmental factors influencing the performance of laboratory rodents on learning and memory.Behavioural brain research · 2019Review
- Consequences of Perinatal Cannabis Exposure.Trends in neurosciences · 2019Review
- Early life stress alters transcriptomic patterning across reward circuitry in male and female mice.Nature communications · 2019Article
- Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development.Neurotoxicology and teratologyArticle
- Electroconvulsive Therapy: Mechanisms of Action, Clinical Considerations, and Future Directions.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the prenatal origin of developmental and psychiatric disorders, studies in laboratory animals are imperative. However, the developmental pace differs between humans and animals; hence, corresponding human ages must be estimated to infer the most vulnerable developmental timings in humans. Because rats and mice are extensively used as models in developmental research, a correspondence between human foetal ages and rodents' ages must be precisely determined; thus, developing a translational model is of utmost importance. Optimizing a translational model involves classifying the brain regions according to developmental paces, but previous studies have conducted this classification arbitrarily. Here we used a clustering method and showed that the brain regions can be classified into two groups. To quantify the developmental pace, we gathered data for a range of development events in humans and rodents and created a linear mixed model that translates human developmental timings into the corresponding rat timings. We conducted an automatic classification of brain regions using an EM algorithm and obtained a model to translate human foetal age to rat age. Our model could predict rat developmental timings within 2.5 days of root mean squared error. This result provides useful information for designing animal studies and clinical tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.