Evidence map›Paper›PMID 29222402›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells.

Jocelyn F Krey, Rachel A Dumont, Philip A Wilmarth, Larry L David, Kenneth R Johnson, Peter G Barr-Gillespie

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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  14. Sensory Hair Cells: An Introduction to Structure and Physiology.Integrative and comparative biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jocelyn F KreyOregon Hearing Research Center and Vollum Institute.
Rachel A DumontOregon Hearing Research Center and Vollum Institute.ORCID 0000-0002-8145-4228
Philip A WilmarthDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, and.
Larry L DavidDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, and.
Kenneth R JohnsonThe Jackson Laboratory, Bar Harbor, Maine 04609.
Peter G Barr-GillespieOregon Hearing Research Center and Vollum Institute, gillespp@ohsu.edu.ORCID 0000-0002-9787-5860
Vollum Institute · USOregon Health & Science University · USJackson Laboratory · US

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Hair-Bundle ProteinsR01DC002368 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Peter Gordon Barr-Gillespie · 1994 to 2026
$11.3M
PORTLAND AREA COMMUNICATION RESEARCH CORE CENTERP30DC005983 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NUTTALL, ALFRED L · 2003 to 2017
$9.0M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Hair Bundle Structure and DynamicsR01DC011034 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BARR-GILLESPIE, PETER GORDON · 2010 to 2024
$6.4M
NEI NIH HHS P30 EY010572NIDCD NIH HHS P30 DC005983NIDCD NIH HHS R01 DC002368NIDCD NIH HHS R01 DC011034NINDS NIH HHS P30 NS061800
6 · The paper itself

Abstract

Sensory hair cells require control of physical properties of their apical plasma membranes for normal development and function. Members of the ADP-ribosylation factor (ARF) small GTPase family regulate membrane trafficking and cytoskeletal assembly in many cells. We identified ELMO domain-containing protein 1 (ELMOD1), a guanine nucleoside triphosphatase activating protein (GAP) for ARF6, as the most highly enriched ARF regulator in hair cells. To characterize ELMOD1 control of trafficking, we analyzed mice of both sexes from a strain lacking functional ELMOD1 [roundabout (

Indexed as

ADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsFemaleGTPase-Activating ProteinsGuanosine TriphosphateHair Cells, VestibularHydrolysisMaleMiceMice, Inbred C57BLMice, KnockoutProtein TransportStereociliaADP-Ribosylation Factor 6ADP-Ribosylation FactorsArf6 protein, mouseElmod1 protein, mouseGTPase-Activating ProteinsGuanosine TriphosphateARFhair cellsstereocilia

Identifiers

PMID29222402
PMCPMC5783965
OpenAlexW2755785093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.