ReviewPediatrics2018
Pediatric Disorders of Orthostatic Intolerance.
Review in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 216 citations in OpenAlex.
- The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Syndrome.The Journal of pediatrics · 2019Trial
- Targeting Brain-Body Processes in Postural Tachycardia Syndrome: A Pilot Trial of POts Reprocessing Therapy.Research square · 2026Article
- Clinical characteristics and healthcare utilization of orthostatic dysregulation in Japan: a nationwide descriptive study.BioPsychoSocial medicine · 2026Article
- Feasibility and Preliminary Outcomes of a Brain/Body Intervention for Postural Tachycardia Syndrome (POTS): Pilot Trial of POts Reprocessing Therapy (PORT).Research square · 2026Article
- Postural tachycardia during active standing: diagnostic criteria in adolescents.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Children and adolescents with disorders of gut-brain interaction with comorbid hypermobility and orthostatic intolerance have worse outcomes.Journal of pediatric gastroenterology and nutrition · 2026Article
- An alternative "Port"? Rationale and development process for POts Reprocessing Therapy (PORT), a brain-body therapy for postural tachycardic syndrome (POTS).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Difference in clinical characteristics between functional syncope and vasovagal syncope in children.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Orthostatic Tachycardia-Hypotensive Syndrome: A Novel Form of Orthostatic Intolerance in the Young.Pediatric cardiology · 2026Article
- The Impact of Follow-Up on Etiological Classification of Pediatric Vertigo.Children (Basel, Switzerland) · 2026Article
- Pediatric reflex syncope: updated insights and future directions.European journal of pediatrics · 2026Review
- Patient Characteristics of a Telemedicine Clinic for Pediatric and Young Adult Postural Orthostatic Tachycardia Syndrome.Journal of clinical medicine · 2026Article
- Headache Onset Timing as a Predictor for Comorbid Conditions of Pediatric Primary Headache.Medical sciences (Basel, Switzerland) · 2026Article
- Analysis of adenylate cyclase activity in Japanese children with orthostatic dysregulation.PloS one · 2026Article
- Postural orthostatic tachycardia syndrome in adolescents with ME/CFS - a case control study.Frontiers in pediatrics · 2026Article
- BASCULE Syndrome in Young Children: Two Cases With Temporally Associated Viral Infections and Diagnostic Challenges.Case reports in dermatological medicine · 2026Article
- Association Between Serum Zinc Level and Comorbid Orthostatic Intolerance in Pediatric Patients with Migraine.Nutrients · 2025Article
- Two-year follow-up on multisystem inflammatory syndrome in children (MIS-c): findings from a tertiary paediatric hospital in Latvia.European journal of pediatrics · 2025Article
- Prevalence of Orthostatic Autonomic Dysregulation in Pediatric Concussion.JAMA network open · 2025Article
- Comparative analysis of autonomic nervous system function in patients with postural orthostatic tachycardia syndrome versus a head-up tilt testing-negative cohort.IBRO neuroscience reports · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 1 country.
Funding
Abstract
Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of symptoms or signs that abate when returned to supine, is common in pediatrics. For example, ∼40% of people faint during their lives, half of whom faint during adolescence, and the peak age for first faint is 15 years. Because of this, we describe the most common forms of OI in pediatrics and distinguish between chronic and acute OI. These common forms of OI include initial orthostatic hypotension (which is a frequently seen benign condition in youngsters), true orthostatic hypotension (both neurogenic and nonneurogenic), vasovagal syncope, and postural tachycardia syndrome. We also describe the influences of chronic bed rest and rapid weight loss as aggravating factors and causes of OI. Presenting signs and symptoms are discussed as well as patient evaluation and testing modalities. Putative causes of OI, such as gravitational and exercise deconditioning, immune-mediated disease, mast cell activation, and central hypovolemia, are described as well as frequent comorbidities, such as joint hypermobility, anxiety, and gastrointestinal issues. The medical management of OI is considered, which includes both nonpharmacologic and pharmacologic approaches. Finally, we discuss the prognosis and long-term implications of OI and indicate future directions for research and patient management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.