ArticleJournal of the American Society of Nephrology : JASN2018
Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells.
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In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis.Andrology · 2024Pooled it
- Therapeutic potential of cAMP-mediated lysosomal pH modulation in ATP6V1B2-related neuropathology.Cell death discovery · 2026Article
- Immunomodulatory Functions of Intercalated Cells in Kidney Autoimmunity.bioRxiv : the preprint server for biology · 2025Article
- Proton-Secreting Cells as Drivers of Inflammation and Sperm Dysfunction in LPS-Induced Epididymitis.Function (Oxford, England) · 2025Article
- A novel L-shaped ortho-quinone analog targeting adenosine A2b receptor to inhibit epithelial-mesenchymal transition in colorectal cancer cells.Medical oncology (Northwood, London, England) · 2025Article
- Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis.Function (Oxford, England) · 2025Article
- Cyclic Adenosine Monophosphate Signaling in Chronic Kidney Disease: Molecular Targets and Therapeutic Potentials.International journal of molecular sciences · 2024Review
- 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Anti‑PD1 therapy‑associated distal renal tubular acidosis: A case report.Experimental and therapeutic medicine · 2023Article
- CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis.Cellular and molecular life sciences : CMLS · 2022Article
- Ammonium chloride-induced acidosis exacerbates cystitis and pyelonephritis caused by uropathogenic E. coli.Physiological reports · 2022Article
- Purinergic signaling in the male reproductive tract.Frontiers in endocrinology · 2022Review
- Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury.Journal of nanobiotechnology · 2021Article
- Landscape of GPCR expression along the mouse nephron.American journal of physiology. Renal physiology · 2021Article
- Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.The Journal of clinical investigation · 2020Article
- Adenosine inhibits the basolateral ClAmerican journal of physiology. Renal physiology · 2020Article
- Region-specific transcriptomic and functional signatures of mononuclear phagocytes in the epididymis.Molecular human reproduction · 2020Article
- Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity.Journal of cell science · 2019Article
- Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa.Andrology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Maria A BattistoneProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Anil V NairProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Claire R BartonProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Rachel N LibermanProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Maria A PeraltaProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Diane E CapenProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Dennis BrownProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Sylvie BretonProgram in Membrane Biology, Center for Systems Biology, Nephrology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Breton.sylvie@mgh.harvard.edu.
Massachusetts General Hospital · USCenter for Systems Biology · USHarvard University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTransfer of grant 5R01HD040793 - Intercellular networks and luminal acidification in the male reproductive tractR01HD040793 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI BRETON, SYLVIE · 2001 to 2021
$6.6MRegulation of proton pump trafficking in kidneyR37DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2008 to 2017
$4.0MCELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITYR01DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 1991 to 2006
$2.2MpH-sensing and activation of acid secretion by the V-ATPaseR01DK097124 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BRETON, SYLVIE · 2013 to 2016
$1.5MA Nikon A1R Confocal Microscope SystemS10RR031563 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2011 to 2011
$561kA Zeiss LSM800 confocal microscope with AiryscanS10OD021577 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2016 to 2016
$374kRegulation of proton pump trafficking in kidneyR56DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2018 to 2018
$100kNCRR NIH HHS S10 RR031563NICHD NIH HHS R01 HD040793NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK042956NIDDK NIH HHS R01 DK097124NIDDK NIH HHS R37 DK042956NIDDK NIH HHS R56 DK042956NIH HHS S10 OD021577
Abstract
Acidosis is an important complication of AKI and CKD. Renal intercalated cells (ICs) express the proton pumping vacuolar H
Indexed as
Acid-Base EquilibriumAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAnimalsCell MembraneCyclic AMP-Dependent Protein KinasesEpithelial CellsHomeostasisKidneyMaleMicePhosphorylationProtein Kinase InhibitorsProtein TransportReceptor, Adenosine A2AAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAdora2a protein, mouseadora2b protein, mouseCyclic AMP-Dependent Protein KinasesProtein Kinase InhibitorsReceptor, Adenosine A2AReceptor, Adenosine A2BVacuolar Proton-Translocating ATPasesacid/base balanceadenosineADORA2A and ADORA2Bintercalated cellsproton secretionV-ATPase
Identifiers
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Textmetadata
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.