ArticleEMBO reports2018
Type VI secretion system sheath inter-subunit interactions modulate its contraction.
Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Functional diversity of accessory factors of the type VI secretion system.Journal of bacteriology · 2026Review
- Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes.Nature biotechnology · 2026Article
- Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.Nature communications · 2025Article
- An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano.Nature communications · 2024Article
- Assembly of a unique membrane complex in type VI secretion systems of Bacteroidota.Nature communications · 2024Article
- No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregativeJournal of bacteriology · 2023Article
- Cytoplasmic contractile injection systems mediate cell death in Streptomyces.Nature microbiology · 2023Article
- VgrG Spike Dictates PAAR Requirement for the Assembly of the Type VI Secretion System.Journal of bacteriology · 2023Article
- The C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments.Proteins · 2022Article
- Evolution of Phage Tail Sheath Protein.Viruses · 2022Article
- Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria.Nature microbiology · 2022Article
- Article
- Type VI secretion system killing by commensaleLife · 2021Article
- Type VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute toInfection and immunity · 2021Article
- Polymorphic Toxins and Their Immunity Proteins: Diversity, Evolution, and Mechanisms of Delivery.Annual review of microbiology · 2020Review
- Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity.Journal of bacteriology · 2019Article
- Article
- The Rich Tapestry of Bacterial Protein Translocation Systems.The protein journal · 2019Review
- Structure and Activity of the Type VI Secretion System.Microbiology spectrum · 2019Review
- Bidirectional contraction of a type six secretion system.Nature communications · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretion systems are essential for bacteria to survive and manipulate their environment. The bacterial type VI secretion system (T6SS) generates the force needed for protein translocation by the contraction of a long polymer called sheath. The sheath is a six-start helical assembly of interconnected VipA/VipB subunits. The mechanism of T6SS sheath contraction is unknown. Here, we show that elongating the N-terminal VipA linker or eliminating charge of a specific VipB residue abolishes sheath contraction and delivery of effectors into target cells. Mass spectrometry analysis identified the inner tube protein Hcp, spike protein VgrG, and other components of the T6SS baseplate significantly enriched in samples of the stable non-contractile sheaths. The ability to lock the T6SS in the pre-firing state opens new possibilities for understanding its mode of action.
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Registered trials
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