ReviewHematology. American Society of Hematology. Education Program2017
Anticoagulation with VADs and ECMO: walking the tightrope.
Review in Hematology. American Society of Hematology. Education Program, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Material-Driven Clinical Complications in Mechanical Circulatory Support: From Blood-Material Interactions to Device-Related Adverse Events.Materials (Basel, Switzerland) · 2026Review
- Pediatric Versus Adult Shear-Induced Hemolysis: Are Age-Related Blood Properties the Main Cause for Differences?Artificial organs · 2026Article
- Polymer embedding of membrane lungs for histological investigations of intra-device clot formation.Frontiers in cardiovascular medicine · 2026Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation.Blood advances · 2023Article
- Reduced Intracranial Hemorrhage with Anticoagulation Guideline Implementation.The journal of extra-corporeal technology · 2022Article
- Novel Coagulation Test Detects Anticoagulation Resistance and Is Associated With Thrombotic Events in Pediatric Patients Requiring Extracorporeal Membrane Oxygenation.Critical care explorations · 2022Article
- Article
- Severe thrombocytopenia in adults undergoing extracorporeal membrane oxygenation is predictive of thrombosis.Platelets · 2022Article
- Article
- A Review of Bivalirudin for Pediatric and Adult Mechanical Circulatory Support.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Review
- Microstructured Hollow Fiber Membranes: Potential Fiber Shapes for Extracorporeal Membrane Oxygenators.Membranes · 2021Article
- Development of Coagulation Factor XII Antibodies for Inhibiting Vascular Device-Related Thrombosis.Cellular and molecular bioengineering · 2021Article
- Neurological Monitoring and Complications of Pediatric Extracorporeal Membrane Oxygenation Support.Pediatric neurology · 2020Review
- Post-operative of bleeding, haemolysis and coagulation in mechanical circulatory support patients.Annals of translational medicine · 2020Review
- Therapeutic Anticoagulation with Argatroban and Heparins Reduces Granulocyte Migration: Possible Impact on ECLS-Therapy?Cardiovascular therapeutics · 2020Article
- Hemostatic complications associated with ventricular assist devices.Research and practice in thrombosis and haemostasis · 2019Review
- Preventing and managing catastrophic bleeding during extracorporeal circulation.Hematology. American Society of Hematology. Education Program · 2018Review
- An introduction to point-of-care testing in extracorporeal circulation and LVADs.Hematology. American Society of Hematology. Education Program · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of devices for mechanical circulatory support (MCS), including ventricular assist devices (VADs) for patients with heart failure and extracorporeal membrane oxygenation (ECMO) for patients with acute cardiac or respiratory failure, has improved survival for subsets of critically ill children and adults. The devices are intricate and complex, allowing blood to bypass the heart or lungs (or both). As blood flows through these artificial devices, normal hemostasis is disrupted, coagulation is promoted, and in the absence of anticoagulation, a thrombus may form in the device, resulting in device failure or embolic stroke. Therefore, anticoagulation is necessary to prevent thrombus formation and maintain device function. However, patients on MCS also have very high bleeding rates. Titrating anticoagulation to prevent hemorrhagic complications and thrombotic events can be a challenge, and hematologists may be consulted in complex cases. Substantial variability remains in the approach to anticoagulant and antiplatelet therapy for patients on MCS, largely because of the lack of high-quality data. Improvements in the design and manufacture of these devices, as well as in the individualized titration of antithrombotic intensity, are expected to enhance outcomes. Several factors pertaining to both the device and the patient (adult and children) should be considered when attempting to optimize this delicate balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.