ReviewHematology. American Society of Hematology. Education Program2017
Should we diagnose and treat distal deep vein thrombosis?
Review in Hematology. American Society of Hematology. Education Program, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Ultrasound screening for asymptomatic deep vein thrombosis in critically ill patients: a pilot trial.Internal and emergency medicine · 2022Trial
- Individualized predictions of early isolated distal deep vein thrombosis in patients with acute ischemic stroke: a retrospective study.BMC geriatrics · 2021Trial
- Dynamic Evolution Characteristics and Nursing Intervention Windows of Perioperative Deep Vein Thrombosis in Patients with Lower Extremity Traumatic Fractures: A Prospective Cohort Study.Therapeutics and clinical risk management · 2026Article
- Treatment of isolated distal deep vein thrombosis: an international survey of healthcare professionals.Journal of thrombosis and thrombolysis · 2025Article
- Predictive nomogram for postoperative lower-limb deep vein thrombosis in patients undergoing endoscopic endonasal surgery during hospitalization: a retrospective cohort study.Scientific reports · 2025Article
- Management of Thromboembolic Disease in Patients with Primary and Metastatic Brain Tumors.Current treatment options in oncology · 2023Review
- Unfractionated heparin versus enoxaparin for venous thromboembolism prophylaxis in intensive care units: a propensity score adjusted analysis.Journal of thrombosis and thrombolysis · 2023Article
- Catheter-Directed Interventions for the Treatment of Lower Extremity Deep Vein Thrombosis.Life (Basel, Switzerland) · 2022Review
- Profile of Patients with Isolated Distal Deep Vein Thrombosis versus Proximal Deep Vein Thrombosis or Pulmonary Embolism: RE-COVERY DVT/PE Study.Seminars in thrombosis and hemostasis · 2022Observational
- Joint Guideline on Venous Thromboembolism - 2022.Arquivos brasileiros de cardiologia · 2022Article
- Development of Risk Prediction Model for Muscular Calf Vein Thrombosis with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of general medicine · 2022Article
- Prevalence of femoral vein duplication: systematic review and metaanalysis.Journal of ultrasonography · 2021Article
- Isolated calf deep venous thrombosis: frequency on venous ultrasound and clinical characteristics.BMC emergency medicine · 2021Article
- Management of isolated distal deep-vein thrombosis with direct oral anticoagulants in the RIETE registry.Journal of thrombosis and thrombolysis · 2021Article
- Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study.Journal de medecine vasculaire · 2021Article
- Venous Thromboembolism in Hospitalized Critical and Noncritical COVID-19 Patients: A Systematic Review and Meta-analysis.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Short-duration chemoprophylaxis might reduce incidence of deep vein thrombosis in Asian patients undergoing total knee arthroplasty.Knee surgery & related research · 2020Article
- Current Challenges in Diagnosis of Venous Thromboembolism.Journal of clinical medicine · 2020Review
- Catheter-Based Therapies and Other Management Strategies for Deep Vein Thrombosis and Post-Thrombotic Syndrome.Journal of clinical medicine · 2020Review
- Deep Venous Thrombosis in a Patient with a Moderate Pretest Probability and a Negative D-Dimer Test: A Review of the Diagnostic Algorithms.Journal of blood medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound series report that isolated distal deep vein thrombosis (DVT), also known as calf DVT, represents up to 50% of all lower-limb DVTs and, therefore, is a frequent medical condition. Unlike proximal DVT and pulmonary embolism, which have been studied extensively and for which management is well standardized, much less is known about the optimal management of isolated calf DVT. Recent data arising from registries and nonrandomized studies have suggested that most distal DVTs do not extend to the proximal veins and have an uneventful follow-up when left untreated. These data had some impact on the international recommendations that recently stated that ultrasound surveillance instead of systematic therapeutic anticoagulation might be an option for selected low-risk patients. However, robust data from randomized studies are scarce. Only 5 randomized trials assessing the need for anticoagulation for calf DVT have been published. Many of these trials had an open-label design and were affected by methodological limitations. The only randomized placebo-controlled trial included low-risk patients (outpatients without cancer or previous venous thromboembolism [VTE]) and was hampered by limited statistical power. Nevertheless, data from this trial confirmed that the use of therapeutic anticoagulation in low-risk patients with symptomatic calf DVT is not superior to placebo in reducing VTE but is associated with a significantly higher risk of bleeding. Further randomized studies are needed to define the best therapy for high-risk patients (inpatients, patients with active cancer, or patients with previous VTE) and the optimal dose and duration of treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.