Evidence map›Paper›PMID 29222172›Full record

ArticleMolecular cancer research : MCR2018

Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression.

David A Drew, Allen Mo, James J Grady, Richard G Stevens, Joel B Levine, Bruce M Brenner, Joseph C Anderson, Faripour Forouhar, Michael J O'Brien, Thomas J Devers and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  4. Safety assessment of titanium dioxide (E171) as a food additive.EFSA journal. European Food Safety Authority · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

David A Drew *Center for Molecular Medicine, University of Connecticut Health, Farmington, Connecticut.
Allen Mo *Center for Molecular Medicine, University of Connecticut Health, Farmington, Connecticut.
James J GradyConnecticut Institute for Clinical and Translational Science, University of Connecticut Health, Farmington, Connecticut.
Richard G StevensDivision of Epidemiology and Biostatistics, University of Connecticut Health, Farmington, Connecticut.
Joel B LevineColon Cancer Prevention Program, University of Connecticut Health, Farmington, Connecticut.
Bruce M BrennerDivision of Gastroenterology, University of Connecticut Health, Farmington, Connecticut.
Joseph C AndersonDivision of Gastroenterology, University of Connecticut Health, Farmington, Connecticut.
Faripour ForouharDepartment of Anatomic Pathology, School of Medicine, University of Connecticut Health, Farmington, Connecticut.
Michael J O'BrienDepartment of Pathology, School of Medicine, Boston University, Boston, Massachusetts.
Thomas J DeversDivision of Gastroenterology, University of Connecticut Health, Farmington, Connecticut.
Daniel W RosenbergCenter for Molecular Medicine, University of Connecticut Health, Farmington, Connecticut. rosenberg@uchc.edu.
UConn Health · USBoston University · USCommunity Care · US

Funding

MOLECULAR CHARACTERIZATION OF ACF (ABERRANT CRYPT FOCI)R01CA081428 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI ROSENBERG, DANIEL WILLIAM · 1999 to 2008
$2.0M
Are ACF Surrogate Markers for Chemoprevention?R01CA159976 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROSENBERG, DANIEL WILLIAM · 2012 to 2016
$1.9M
NCI NIH HHS R01 CA081428NCI NIH HHS R01 CA159976
6 · The paper itself

Abstract

Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesion found within the human colon. Despite their relatively high frequency in the distal colon, few studies have examined the molecular characteristics of ACF within the proximal colon. In the following study, clinical participants (

Indexed as

Aberrant Crypt FociColonic NeoplasmsDisease ProgressionFemaleHumansMaleMiddle AgedNeoplasms, Multiple Primary

Identifiers

PMID29222172
PMCPMC5835173
OpenAlexW2771584793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.