Evidence map›Paper›PMID 29222167›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP.

Padmaja Jakka, Bindu Bhargavi, Swapna Namani, Subathra Murugan, Gary Splitter, Girish Radhakrishnan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Infection and immunity · 2024
    Article
  7. Review
  8. Review
  9. Frontiers in cellular and infection microbiology · 2024
    Review
  10. Article
  11. Article
  12. TIRAP in the Mechanism of Inflammation.Frontiers in immunology · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Padmaja JakkaNational Institute of Animal Biotechnology, Hyderabad, Telangana 500049, India.ORCID 0000-0002-3090-9456
Bindu BhargaviNational Institute of Animal Biotechnology, Hyderabad, Telangana 500049, India.
Swapna NamaniNational Institute of Animal Biotechnology, Hyderabad, Telangana 500049, India.ORCID 0000-0003-1788-0107
Subathra MuruganNational Institute of Animal Biotechnology, Hyderabad, Telangana 500049, India.
Gary SplitterDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706.
Girish RadhakrishnanNational Institute of Animal Biotechnology, Hyderabad, Telangana 500049, India; girish@niab.org.in.ORCID 0000-0001-9088-0029
National Institute of Animal Biotechnology · INManipal Academy of Higher Education · INUniversity of Wisconsin–Madison · US

Funding

Brucella epitope recognition by CD8+ T cellsR01AI073558 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HARMS, JEROME SCOTT, SMITH, JUDITH ANNE · 2008 to 2016
$3.3M
Brucella TIR protein recruits a ubiquitin ligase to TLR adaptor protein TIRAPR03AI101611 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI DIIOIA, MARINA DURWARD · 2012 to 2012
$75k
NIAID NIH HHS R01 AI073558NIAID NIH HHS R03 AI101611
6 · The paper itself

Abstract

Cytoplasmic linker protein 170 (CLIP170) is a CAP-Gly domain-containing protein that is associated with the plus end of growing microtubules and implicated in various cellular processes, including the regulation of microtubule dynamics, cell migration, and intracellular transport. Our studies revealed a previously unrecognized property and role of CLIP170. We identified CLIP170 as one of the interacting partners of

Indexed as

Signal TransductionAnimalsBiomarkersCell LineCytokinesGene ExpressionGene SilencingHumansImmunohistochemistryInflammation MediatorsLipopolysaccharidesMacrophagesMembrane GlycoproteinsMiceMicrotubule-Associated ProteinsNeoplasm ProteinsBiomarkersCytokinescytoplasmic linker protein 170Inflammation MediatorsLipopolysaccharidesMembrane GlycoproteinsMicrotubule-Associated ProteinsNeoplasm ProteinsNF-kappa BReceptors, Interleukin-1RNA, Small InterferingTIRAP protein, humanTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID29222167
PMCPMC5760445
OpenAlexW2773823208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.