Evidence map›Paper›PMID 29222165›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Innate Sex Bias of

Moriah J Castleman, Srijana Pokhrel, Kathleen D Triplett, Donna F Kusewitt, Bradley O Elmore, Jason A Joyner, Jon K Femling, Geetanjali Sharma, Helen J Hathaway, Eric R Prossnitz and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  8. Review
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  15. Pathogens (Basel, Switzerland) · 2025
    Review
  16. Clinical Features and Antibiotic Susceptibility ofJournal of clinical medicine · 2025
    Article
  17. Article
  18. Estrogen and bacterial infection.Frontiers in immunology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Moriah J CastlemanDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131.ORCID 0000-0001-7219-5044
Srijana PokhrelDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131.
Kathleen D TriplettDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131.
Donna F KusewittDepartment of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131.
Bradley O ElmoreDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131.
Jason A JoynerDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131.
Jon K FemlingDepartment of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131.ORCID 0000-0001-8369-181X
Geetanjali SharmaDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131; and.
Helen J HathawayDepartment of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131.ORCID 0000-0002-7879-5056
Eric R ProssnitzDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131; and.
Pamela R HallDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM 87131; phall@salud.unm.edu.ORCID 0000-0003-2367-3382
University of New Mexico · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Molecular Mechanisms and Applications of Novel ER/GPER-selective LigandsR01CA194496 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ARTERBURN, JEFFREY B, PROSSNITZ, ERIC R · 2016 to 2025
$4.1M
University of New Mexico Clinical and Translational Science CenterKL2TR001448 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2015 to 2024
$3.5M
G protein-coupled estrogen receptor GPER and breast carcinogenesisR01CA163890 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PROSSNITZ, ERIC R · 2012 to 2023
$3.3M
Apolipoprotein B and Control of S. aureus Quorum SensingR01AI091917 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HALL, PAMELA RANEL · 2011 to 2015
$1.9M
Development of GPR30-Selective LigandsR01CA127731 · NCI · UNIVERSITY OF NEW MEXICO · PI ARTERBURN, JEFFREY B, OPREA, TUDOR I · 2008 to 2012
$1.7M
Sex-dependent phagocyte clearance of Staphylococcus aureusR21AI128159 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HALL, PAMELA RANEL · 2017 to 2018
$411k
NCATS NIH HHS KL2 TR001448NCATS NIH HHS UL1 TR001449NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA127731NCI NIH HHS R01 CA163890NCI NIH HHS R01 CA194496NIAID NIH HHS R01 AI091917NIAID NIH HHS R21 AI128159
6 · The paper itself

Abstract

Numerous studies have reported sex bias in infectious diseases, with bias direction dependent on pathogen and site of infection.

Indexed as

AnimalsBacterial ToxinsCytokinesDisease Models, AnimalDisease ResistanceEstrogensFemaleGene ExpressionHemolysin ProteinsImmunity, InnateInflammasomesInflammation MediatorsMaleMiceMicrobial ViabilityNeutrophilsBacterial ToxinsCytokinesEstrogensHemolysin ProteinsInflammasomesInflammation Mediatorsstaphylococcal alpha-toxinVirulence Factors

Identifiers

PMID29222165
PMCPMC5760295
OpenAlexW2773861638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.