Evidence map›Paper›PMID 29222092›Full record

ArticleClinical science (London, England : 1979)2018

Targeted disruption of the

Iris Hardege, Lu Long, Raya Al Maskari, Nicola Figg, Kevin M O'Shaughnessy

Open access · hybridAbstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. The ex vivo perfused mouse adrenal gland-a new model to study aldosterone secretion.Pflugers Archiv : European journal of physiology · 2024
    Article
  4. Article
  5. Article
  6. DNA Methylation of the Angiotensinogen Gene,International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Iris HardegeDepartment of Medicine, EMIT Division, Addenbrooke's Hospital, Hills Road, Cambridge, U.K.
Lu LongDepartment of Medicine, EMIT Division, Addenbrooke's Hospital, Hills Road, Cambridge, U.K.
Raya Al MaskariDepartment of Medicine, EMIT Division, Addenbrooke's Hospital, Hills Road, Cambridge, U.K.
Nicola FiggDepartment of Medicine, CVD Division, Addenbrooke's Hospital, Hills Road, Cambridge, U.K.
Kevin M O'ShaughnessyDepartment of Medicine, EMIT Division, Addenbrooke's Hospital, Hills Road, Cambridge, U.K. kmo22@medschl.cam.ac.uk.ORCID 0000-0002-1476-7566
Addenbrooke's Hospital · GB

Funding

British Heart Foundation FS/12/78/29875
6 · The paper itself

Abstract

Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (

Indexed as

Gene Expression ProfilingAldosteroneAngiotensin IIAnimalsCell Line, TumorCytochrome P-450 CYP11B2FemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHumansMaleMice, Inbred C57BLMice, KnockoutSex FactorsVasoconstrictor AgentsZona GlomerulosaAldosteroneAngiotensin IICytochrome P-450 CYP11B2G Protein-Coupled Inwardly-Rectifying Potassium ChannelsKcnj5 protein, mouseVasoconstrictor AgentsaldosteroneGIRK4 K channelKCNJ5 geneknockout miceRNAseq

Identifiers

PMID29222092
PMCPMC6365593
OpenAlexW2773045490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.