Evidence map›Paper›PMID 29222023›Full record

ArticleNeuroscience letters2018

Regional brain gray matter changes in adolescents with single ventricle heart disease.

Sadhana Singh, Rajesh Kumar, Bhaswati Roy, Mary A Woo, Alan Lewis, Nancy Halnon, Nancy Pike

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sadhana SinghDepartment of Anesthesiology, University of California, Los Angeles, CA, USA.
Rajesh KumarDepartment of Anesthesiology, University of California, Los Angeles, CA, USA; Department of Radiological Sciences, University of California, Los Angeles, CA, USA; Department of Bioengineering, University of California, Los Angeles, CA, USA; Brain Research Institute, University of California, Los Angeles, CA, USA. Electronic address: rkumar@mednet.ucla.edu.
Bhaswati RoyUCLA School of Nursing, University of California, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California, Los Angeles, CA, USA.
Alan LewisDivision of Pediatric Cardiology, Children's Hospital, Los Angeles, CA, USA.
Nancy HalnonDivision of Pediatric Cardiology, University of California, Los Angeles, CA, USA.
Nancy PikeUCLA School of Nursing, University of California, Los Angeles, CA, USA. Electronic address: npike@sonnet.ucla.edu.
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
Memory and Brain Structure in Adolescents with Single Ventricle Heart DiseaseR01NR013930 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIKE, NANCY ANN · 2013 to 2016
$1.4M
NINR NIH HHS R01 NR013930NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

Adolescents with single ventricle heart disease (SVHD) show autonomic, mood, and cognitive deficits, indicating aberrations in brain areas that regulate these functions. However, the gray matter integrity in autonomic, mood, and cognitive control sites is unclear. We examined regional brain gray matter changes, using high-resolution T1-weighted images (3.0-T magnetic resonance scanner) with voxel based morphometry procedures, as well as mood and cognitive functions in SVHD (n=18; age, 15.7±1.1years; male, 10) and controls (n=31; age, 16.0±1.1years; male, 17). High-resolution T1-weighted images were realigned, gray matter tissue type partitioned, normalized to a common space, smoothed, and compared between groups (analysis of covariance; covariates, age and gender). The mood and cognitive scores were compared between groups using independent samples t-tests. SVHD subjects showed significantly altered mood and cognitive functions over controls. Significantly reduced gray matter emerged in multiple brain areas, including the thalamus, caudate nuclei, putamen, insula, prefrontal, post-central and precentral gyrus, occipital gyrus, para-hippocampal gyrus, temporal gyrus, and cerebellar sites in SVHD over controls. SVHD subjects show compromised gray matter integrity in autonomic, mood and cognitive control sites. The findings indicate that frequent deficits found in SVHD subjects have a brain structural basis in the condition.

Indexed as

Brain MappingAdolescentAffective SymptomsCerebral CortexCognitionCognitive DysfunctionFemaleGray MatterHeart DiseasesHumansMagnetic Resonance ImagingMaleCognitionCongenital heart diseaseGray matterMagnetic resonance imagingVoxel based morphometry

Identifiers

PMID29222023
PMCPMC5801206
OpenAlexW2773259175

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.