ArticleAnaerobe2018
Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination.
Article in Anaerobe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination.PLoS biology · 2026Article
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- Unravelling three-way interactions betweenJournal of medical microbiology · 2025Review
- Phenotypic analysis of variousApplied and environmental microbiology · 2025Article
- Identification of two glycosyltransferases required for synthesis of membrane glycolipids inmBio · 2025Article
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- Bile acids as germinants for Clostridioides difficile spores, evidence of adaptation to the gut?FEMS microbiology reviews · 2025Review
- Identification of two glycosyltransferases required for synthesis of membrane glycolipids inbioRxiv : the preprint server for biology · 2025Article
- Phenotypic analysis of variousbioRxiv : the preprint server for biology · 2025Article
- The Impact of YabG Mutations on Clostridioides difficile Spore Germination and Processing of Spore Substrates.Molecular microbiology · 2024Article
- Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections.Pathogens (Basel, Switzerland) · 2024Review
- The impact of YabG mutations onbioRxiv : the preprint server for biology · 2024Article
- Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae.iMeta · 2024Article
- Correlating Antibiotic-Induced Dysbiosis toACS infectious diseases · 2023Article
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- Intestinal bile acids provide a surmountable barrier againstProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle ofAntimicrobial agents and chemotherapy · 2023Article
- Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model.The Journal of infectious diseases · 2023Article
- A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs.Communications biology · 2023Article
- Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation.NPJ biofilms and microbiomes · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bile acids are an important signal for germination of Clostridioides difficile spores; however, the bile acid signal alone is not sufficient. Amino acids, such as glycine, are another signal necessary for germination by C. difficile spores. Prior studies on the amino acid signal required for germination have shown that there is a preference for the amino acid used as a signal for germination. Previously we found that d-alanine can function as a co-germinant for C. difficile spores at 37 °C but not at 25 °C. Here, we tested the ability of other amino acids to act as co-germinants with taurocholate (TA) at 37 °C and found that many amino acids previously categorized as non-co-germinants are co-germinants at 37 °C. Based on the EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.