Evidence map›Paper›PMID 29221858›Full record

ArticlePhotodiagnosis and photodynamic therapy2018

Photochemical internalization enhanced macrophage delivered chemotherapy.

Diane Shin, Catherine Christie, David Ju, Rohit Kumar Nair, Stephanie Molina, Kristian Berg, Tatiana B Krasieva, Steen J Madsen, Henry Hirschberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Photodynamic therapy mediated immune therapy of brain tumors.Neuroimmunology and neuroinflammation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Diane ShinBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States. Electronic address: diane.shin77@gmail.com.
Catherine ChristieBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States.
David JuBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States.
Rohit Kumar NairBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States.
Stephanie MolinaDept. of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas 4505 S. Maryland Pkwy, Las Vegas, NV, 89154-3037, United States.
Kristian BergDept. of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310, Oslo, Norway.
Tatiana B KrasievaBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States.
Steen J MadsenDept. of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas 4505 S. Maryland Pkwy, Las Vegas, NV, 89154-3037, United States.
Henry HirschbergBeckman Laser Institute and Medical Clinic, University of California, Irvine 1002 Health Sciences Rd, Irvine, CA, 92617, United States.
University of California, Irvine · USUniversity of Nevada, Las Vegas · USOslo University Hospital · NO

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI VENUGOPALAN, VASAN · 2012 to 2017
$7.0M
NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

backgroundMacrophage (Ma) vectorization of chemotherapeutic drugs has the advantage for cancer therapy in that it can actively target and maintain an elevated concentration of drugs at the tumor site, preventing their spread into healthy tissue. A potential drawback is the inability to deliver a sufficient number of drug-loaded Ma into the tumor, thus limiting the amount of active drug delivered. This study examined the ability of photochemical internalization (PCI) to enhance the efficacy of released drug by Ma transport.

methodsTumor spheroids consisting of either F98 rat glioma cells or F98 cells combined with a subpopulation of empty or doxorubicin (DOX)-loaded mouse Ma (RAW264.7) were used as in vitro tumor models. PCI was performed with the photosensitizer AlPcS

resultsRAW264.7 Ma pulsed with DOX released the majority of the incorporated DOX within two hours of incubation. PCI significantly increased the toxicity of DOX either as pure drug or derived from monolayers of DOX-loaded Ma. Significant growth inhibition of hybrid spheroids was also observed with PCI even at subpopulations of DOX-loaded Ma as low as 11% of the total initial hybrid spheroid cell number.

conclusionResults show that RAW264.7 Ma, pulsed with DOX, could effectively incorporate and release DOX. PCI significantly increased the ability of both free and Ma-released DOX to inhibit the growth of tumor spheroids in vitro. The growth of F98 + DOX loaded Ma hybrid spheroids were synergistically reduced by PCI, compared to either photodynamic therapy or released DOX acting alone.

Indexed as

AnimalsCell Line, TumorDoxorubicinDrug CarriersEndocytosisGliomaIndolesMacrophagesMiceOrganometallic CompoundsPhotochemotherapyPhotosensitizing AgentsRatsaluminum phthalocyanine disulfonateDoxorubicinDrug CarriersIndolesOrganometallic CompoundsPhotosensitizing AgentsDoxorubicinMacrophage drug deliveryPCIPDTPhotochemical internalizationPhotodynamic therapy

Identifiers

PMID29221858
PMCPMC5873960
OpenAlexW2773091254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.