Trial reportSleep medicine2017
Prevalence of sleep apnea at the acute phase of ischemic stroke with or without thrombolysis.
Trial report in Sleep medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01861275 (Obstructive Sleep Apnea as a Risk Factor for Ischaemic Stroke , a Prospective Study), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Obstructive Sleep Apnea as a Risk Factor for Ischaemic Stroke , a Prospective Study
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence, Trajectory, and Factors Associated With Patient-Reported Nonmotor Outcomes After Stroke: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- A Two-Sample Mendelian Randomization Research Examining the Causal Association Between Ischemic Stroke and Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Obstructive sleep apnea exaggeration as predictor of poor outcome post thrombolytic stroke.Radiology case reports · 2024Article
- Prevalence, incidence, and the time trends of sleep-disordered breathing among patients with stroke: a systematic review and meta-analysis.Frontiers in neurology · 2024Review
- OSASUD: A dataset of stroke unit recordings for the detection of Obstructive Sleep Apnea Syndrome.Scientific data · 2022Article
- Wake-up strokes are linked to obstructive sleep apnea and worse early functional outcome.Brain and behavior · 2021Observational
- The application of the emergency green channel integrated management strategy in intravenous thrombolytic therapy for AIS.American journal of translational research · 2021Article
- Central sleep apnea is uncommon after stroke.Sleep medicine · 2021Article
- Relationship between SDB and short-term outcome in Finnish ischemic stroke patients.Brain and behavior · 2020Observational
- Evaluation of an OSA risk stratifying and treatment protocol during inpatient rehabilitation of post-stroke patients.Sleep & breathing = Schlaf & Atmung · 2020Observational
- The Evolution of Sleep Apnea Six Months After Acute Ischemic Stroke and Thrombolysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Obstructive sleep apnea and stroke: hand in hand?Journal of thoracic disease · 2018Article
- Post-stroke insomnia: multidimensional mechanisms, clinical heterogeneity, and toward mechanism-informed, objectively quantified management.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the study was to compare the prevalence, type, and severity of sleep apnea during the acute phase of ischemic stroke among patients either receiving or not receiving thrombolysis.
methodsWe recruited 246 consecutive adult ischemic stroke patients. Patients underwent cardiorespiratory sleep study with portable three-channel device during the first 48 h after the symptom onset of ischemic stroke.
resultsWe enrolled 110 (65.5% male) stroke patients in the thrombolysis group and 94 (59.6% male) in the nonthrombolysis group. In the thrombolysis group, the median National Institutes of Health Stroke Scale (NIHSS) score was higher (5.5) compared to the nonthrombolysis group (2.0) (p < 0.001). There was a lower incidence of lacunar (17.3% vs 36.2%, p = 0.002) and cerebellar (2.7% vs 16.0%, p < 0.001) strokes and a higher frequency of middle cerebral artery syndrome (60.9% vs 33.0%, p < 0.001) in the thrombolysis group compared to the nonthrombolysis group. Sleep apnea defined as an apnea-hypopnea index (AHI) ≥ 5/h was diagnosed in 186 (91.2%) patients, its prevalence being higher in the thrombolysis (96.4%) compared to the nonthrombolysis (85.1%) group (p = 0.007). The mean baseline AHI was 33.7/h in the thrombolysis group compared to 26.8/h in the nonthrombolysis group (p = 0.017).
conclusionSleep apnea was present in the vast majority of ischemic stroke patients. The stroke patients treated with thrombolysis were more likely to have sleep apnea, to have elevated NIHSS score at admission, and to be younger. Sleep apnea was more severe among those receiving thrombolysis as compared to those who were not. CLINICAL
trial registrationURL: http://www.clinicaltrials.cov. Unique identifier: NCT01861275.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.