Evidence map›Paper›PMID 29221750›Full record

Observational studyThe Journal of thoracic and cardiovascular surgery2018

Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study.

Brian C Gulack, Katherine A Kirkwood, Wei Shi, Peter K Smith, John H Alexander, Sandra G Burks, Annetine C Gelijns, Vinod H Thourani, Daniel Bell, Ann Greenberg and 4 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06603961 (Efficacy of Customized Pressure-Guided Elastic Bandages in Preventing Postoperative Edema and Complications in Coronary Artery Bypass Graft), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06603961 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Customized Pressure-Guided Elastic Bandages in Preventing Postoperative Edema and Complications in Coronary Artery Bypass Graft (CABG) Patients: A Comparative Study of Compression Therapy and Standard Post-CABG Care.

TypeinterventionalSponsorSiriraj HospitalRan2025 to 2026Enrolled106ConditionsLimb Edema, Surgical Site Infections, Leg Swelling, Compression BandagesArmsCPG-EB group
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

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  12. Unachievable zeros.Journal of thoracic disease · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Brian C GulackDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke Health, Durham, NC.
Katherine A KirkwoodInternational Center for Health Outcomes and Innovation Research (InCHOIR) in the Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY.
Wei ShiInternational Center for Health Outcomes and Innovation Research (InCHOIR) in the Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY.
Peter K SmithDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke Health, Durham, NC.
John H AlexanderDivision of Cardiology, Duke Clinical Research Institute, Duke Health, Durham, NC.
Sandra G BurksDivision of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Va.
Annetine C GelijnsInternational Center for Health Outcomes and Innovation Research (InCHOIR) in the Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY. Electronic address: annetine.gelijns@mssm.edu.
Vinod H ThouraniDepartment of Cardiac Surgery, MedStar Heart and Vascular Institute, Washington Hospital Center, Washington, DC.
Daniel BellDivision of Cardiothoracic Surgery, Columbia University Medical Center, New York, NY.
Ann GreenbergDepartment of Cardiothoracic Surgery, NIH Heart Center at Suburban Hospital, Bethesda, Md.
Seth D GoldfarbInternational Center for Health Outcomes and Innovation Research (InCHOIR) in the Department of Population Health Science and Policy, Icahn School of Medicine, New York, NY.
Mary Lou MayerDepartment of Surgery, Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pa.
Michael E BowdishDepartment of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, Calif.
Cardiothoracic Surgical Trials Network (CTSN)
Center for Innovation · USClinical Research Institute · USDuke University Health System · USColumbia University Irving Medical Center · USUniversity of Pennsylvania · USUniversity of Southern California · USSuburban Hospital · USUniversity of Virginia · USMedStar Heart & Vascular Institute · USWashington Hospital · US

Funding

REVISED CAROL ACT IIU01HL088942 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELIJNS, ANNE CHRISTINE, MOSKOWITZ, ALAN J · 2007 to 2025
$122.6M
USC Cardiothoracic Surgical Trials Network Core Clinical CenterUM1HL117924 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLEN, KEITH B., STARNES, VAUGHN A · 2013 to 2025
$7.0M
NHLBI NIH HHS U01 HL088942NHLBI NIH HHS UM1 HL117924
6 · The paper itself

Abstract

objectiveTo analyze patient risk factors and processes of care associated with secondary surgical-site infection (SSI) after coronary artery bypass grafting (CABG).

methodsData were collected prospectively between February and October 2010 for consenting adult patients undergoing CABG with saphenous vein graft (SVG) conduits. Patients who developed a deep or superficial SSI of the leg or groin within 65 days of CABG were compared with those who did not develop a secondary SSI.

resultsAmong 2174 patients identified, 65 (3.0%) developed a secondary SSI. Median time to diagnosis was 16 days (interquartile range 11-29) with the majority (86%) diagnosed after discharge. Gram-positive bacteria were most common. Readmission was more common in patients with a secondary SSI (34% vs 17%, P < .01). After adjustment, an open SVG harvest approach was associated with an increased risk of secondary SSI (adjusted hazard ratio [HR], 2.12; 95% confidence interval [CI], 1.28-3.48). Increased body mass index (adjusted HR, 1.08, 95% CI, 1.04-1.12) and packed red blood cell transfusions (adjusted HR, 1.13; 95% CI, 1.05-1.22) were associated with a greater risk of secondary SSI. Antibiotic type, antibiotic duration, and postoperative hyperglycemia were not associated with risk of secondary SSI.

conclusionsSecondary SSI after CABG continues to be an important source of morbidity. This serious complication often occurs after discharge and is associated with open SVG harvesting, larger body mass, and blood transfusions. Patients with a secondary SSI have longer lengths of stay and are readmitted more frequently.

Indexed as

AgedAnti-Bacterial AgentsBody Mass IndexCoronary Artery BypassErythrocyte TransfusionFemaleHumansIncidenceLength of StayMaleMiddle AgedPatient ReadmissionProspective StudiesRisk AssessmentRisk FactorsSaphenous VeinAnti-Bacterial Agentsbody mass indexcoronary artery bypass graftingpostoperative length of staypostoperative readmissionred blood cell transfusionsaphenous vein graftsurgical site infection

Identifiers

PMID29221750
PMCPMC5860945
OpenAlexW2766184630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.