ArticleImmunity2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 94 citations in OpenAlex.
- Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate.Nature immunology · 2026Article
- Molecular Signature and miRNA Pattern of CD4 + T Lymphocytes in Plaque Psoriasis.Clinical reviews in allergy & immunology · 2026Review
- CD8Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response.Journal of translational medicine · 2026Article
- Single-cell and spatial transcriptomics reveal transplant-associated T cells and myeloid cells in human liver transplantation.Frontiers in immunology · 2026Article
- Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?Trends in immunology · 2025Review
- IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis.Nature immunology · 2025Article
- Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection.The Journal of clinical investigation · 2025Article
- Antisense oligonucleotides targeting IRF4 alleviate psoriasis.Acta pharmaceutica Sinica. B · 2025Article
- Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival.Chinese medical journal · 2025Article
- Dissecting the immune discrepancies in mouse liver allograft tolerance and heart/kidney allograft rejection.Cell proliferation · 2024Article
- CD4Nature immunology · 2024Article
- Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis.Oncoimmunology · 2024Article
- The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8Cellular & molecular immunology · 2023Article
- Article
- Immune Checkpoints in Solid Organ Transplantation.Biology · 2023Review
- Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.Nature immunology · 2023Article
- A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.Science immunology · 2023Article
- Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8Research (Washington, D.C.) · 2023Article
- Small-molecule BCL6 inhibitor protects chronic cardiac transplant rejection and inhibits T follicular helper cell expansion and humoral response.Frontiers in pharmacology · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Jie WuImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Hedong ZhangImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA.
Xiaomin ShiImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA.
Xiang XiaoImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA.
Yihui FanImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA.
Laurie J MinzeImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA.
Jin WangImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Rafik M GhobrialImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Jiahong XiaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Roger SciammasImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA.
Xian C LiImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
Wenhao ChenImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Texas Medical Center, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA. Electronic address: wchen@houstonmethodist.org.
Houston Methodist · USTexas Medical Center · USCornell University · USUnion Hospital · CN
Funding
Control of Treg exhaustion by OX40R01AI106200 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2014 to 2025
$4.2MNIAID NIH HHS R01 AI106200
Abstract
CD4
Indexed as
Graft SurvivalHeart TransplantationAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell MovementDNA-Binding ProteinsGene Expression ProfilingGene Expression RegulationGraft RejectionGranzymesInterferon-gammaInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-17DNA-Binding ProteinsGranzymesInterferon-gammaInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-17Pdcd1 protein, mouseperforin, mousePore Forming Cytotoxic ProteinsProgrammed Cell Death 1 ReceptorTranscription FactorsZfpn1a2 protein, mouseinterferon regulatory factor 4programmed cell death protein 1T cell dysfunctiontranscriptional regulationtransplant acceptance
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.