ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2018
A population-based evaluation of the natural history of chronic pancreatitis.
Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- The Epidemiology of PRSS1 Hereditary Pancreatitis and Its Clinical Implications: A Systematic Review.Pancreas · 2026Pooled it
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- Minimally invasive versus open lateral pancreaticojejunostomy in patients with painful chronic pancreatitis: systematic review.BJS open · 2024Pooled it
- Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Pooled it
- Article
- Clinical and CT Imaging Features of Chronic Pancreatitis: A Cross-Sectional Study From Vietnam.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- A Self-Reported Electronic Body Map Identifies Distinct Clinical Pain Phenotypes in Chronic Pancreatitis.Clinical and translational gastroenterology · 2026Article
- Long-term outcomes and bleeding risk factors in pancreatic portal hypertension: a retrospective cohort study.BMC gastroenterology · 2026Article
- Chronic pancreatitis and pancreatogenic type 3c diabetes risk: a systematic review and meta-analysis.Therapeutic advances in endocrinology and metabolism · 2026Article
- The Impact of Chronic Pancreatitis Etiology on Clinical Outcomes: A Population-Based Propensity-Matched Analysis.Gastroenterology research · 2025Article
- Nutritional Management in Chronic Pancreatitis: From Exocrine Pancreatic Insufficiency to Precision Therapy.Nutrients · 2025Review
- Impact of Ethno-racial Factors on Clinical Outcomes and Health Care Utilization in Chronic Pancreatitis.Journal of racial and ethnic health disparities · 2025Article
- Decreased Life Expectancy in Patients with Acute and Chronic Pancreatitis.Digestive diseases and sciences · 2025Article
- Risk factors for calcification in chronic pancreatitis: a systematic review and meta-analysis.Frontiers in medicine · 2025Article
- Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview.Frontiers in physiology · 2025Review
- Use of pancreatic endotherapy in patients with chronic pancreatitis: results from a multicenter cohort study in the United States.Gastrointestinal endoscopy · 2024Article
- Validation of the Distinct Entity "Chronic Pancreatitis Without Prior Acute Pancreatitis": Complementary Role of Population- and Clinic-Based Studies.Gastroenterology · 2024Article
- Predictive Factors Correlated with Successful Early Endoscopic Removal of Pancreaticolithiasis in Chronic Pancreatitis after Extracorporeal Shock Wave Lithotripsy.Diagnostics (Basel, Switzerland) · 2024Article
- Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function.Scientific reports · 2023Article
- Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function.Research square · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBased on reports from tertiary care centers, chronic pancreatitis (CP) is considered to be a painful and debilitating disease frequently requiring invasive interventions. Our primary aim was to assess the natural course of CP in a population-based cohort using endoscopic and surgical interventions as surrogates for disease aggressiveness.
methodsWe identified all patients (n = 89, alcoholic [ACP = 46], non-alcoholic [NACP] = 43) with newly diagnosed definite CP from Olmsted County, Minnesota between 1977 and 2006. Patients were followed until death or censoring. Medical records were reviewed at time of diagnosis and during each follow-up. Both lifetime proportions and cumulative incidence since the initial manifestation of CP were estimated and compared. Survival was estimated with Kaplan-Meier methodology.
resultsMedian age at CP diagnosis was 56 years (IQR, 48-67) and 56% were male. During median follow-up of 10 years, 68 (76%) experienced pancreatic pain, but only 27 (30%) needed any invasive therapeutic intervention: 23% had endotherapy and 11% had pancreatic surgery. During the clinical course, when compared with NACP, ACP patients had significantly more (all p < 0.05) pain (87 vs. 65%), recurrent acute pancreatitis (44 vs. 23%), pseudocysts (41 vs. 16%), cumulative incidence of exocrine insufficiency (60 vs. 21%), and annual hospitalizations after CP diagnosis (0.79 vs. 0.25). The cumulative risk of diabetes, calcifications, surgery and overall survival was similar in ACP and NACP.
conclusionsOur study suggests that CP at a population level may have a milder course than that reported from tertiary centers. We confirm that ACP has a more severe phenotype than NACP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.