ArticleBMC cardiovascular disorders2017
Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Equine models in translational medicine: A comparative approach to human health.Animal models and experimental medicine · 2026Review
- Animal and cellular models of atrial fibrillation: a review.Frontiers in cardiovascular medicine · 2025Review
- Atrial fibrillatory rate as predictor of recurrence of atrial fibrillation in horses treated medically or with electrical cardioversion.Equine veterinary journal · 2022Article
- Paroxysmal Atrial Fibrillation in Horses: Pathophysiology, Diagnostics and Clinical Aspects.Animals : an open access journal from MDPI · 2022Review
- Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation.International journal of cardiology. Heart & vasculature · 2021Article
- Incidence, recurrence, and outcome of postrace atrial fibrillation in Thoroughbred horses.Journal of veterinary internal medicine · 2021Article
- ECG Restitution Analysis and Machine Learning to Detect Paroxysmal Atrial Fibrillation: Insight from the Equine Athlete as a Model for Human Athletes.Function (Oxford, England) · 2021Article
- Effect of selective IBritish journal of pharmacology · 2020Article
- Longitudinal study of electrical, functional and structural remodelling in an equine model of atrial fibrillation.BMC cardiovascular disorders · 2019Article
- Effects of dofetilide and ranolazine on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.Journal of cardiovascular electrophysiology · 2019Article
- Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses.Journal of veterinary internal medicine · 2018Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAtrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported.
aimThe aim was to study characteristics of induced AF and its modification by flecainide.
methodsThe study group consisted on 3 horses with spontaneous persistent AF and 13 with pace-induced AF. Seven horses were treated with saline (control) and eight with flecainide (2 mg/kg). ECGs were analysed using spatiotemporal cancellation of QRST complexes and calculation of AFR from the residual atrial signal.
resultsAt AF onset, AFR was 295 ± 52 fibrillations per minute (fpm) in the horses with induced AF treated with flecainide, 269 ± 36 fpm in the control group (ns), and 364 ± 26 fpm in the horses with spontaneous persistent AF (P < 0.05 compared to the control group). Flecainide caused a decrease in AFR in all animals and restored sinus rhythm in the animals with induced AF. In the control animals, AFR increased from 269 ± 36 fpm to a plateau of 313 ± 14 fpm before decreasing to 288 ± 28 fpm during the last 10% of the AF episodes preceding spontaneous conversion (P < 0.05).
conclusionAFR in horses with induced AF resembles AFR in humans with paroxysmal AF. Flecainide caused a rapid decrease in AFR in all horses, further supporting the method to be a non-invasive technique to study the effect of antiarrhythmic compounds.
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