Evidence map›Paper›PMID 29221140›Full record

ArticleOncotarget2017

Missing-in-metastasis B (MIM-B) combined with caveolin-1 promotes metastasis of hepatocellular carcinoma.

Xiu-Yan Huang, Zi-Li Huang, Tao Niu, Zhen-Qian Wu, Bin Xu, Yong-Hua Xu, Xin-Yu Huang, Qi Zheng, Jian Zhou, Zi Chen and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. MTSS1: beyond the integration of actin and membrane dynamics.Cellular and molecular life sciences : CMLS · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Xiu-Yan Huang *Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Zi-Li Huang *Department of Radiology, Xuhui Central Hospital, Shanghai, P.R. China.
Tao Niu *Department of General Surgery, People's Hospital of Menghai County, Yunnan Province, P.R. China.
Zhen-Qian Wu *Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Bin Xu *Department of General Surgery, The Tenth People's Hospital of Tongji University, Shanghai, P.R. China.
Yong-Hua XuDepartment of Radiology, Xuhui Central Hospital, Shanghai, P.R. China.
Xin-Yu HuangDepartment of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Qi ZhengDepartment of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, P.R. China.
Jian ZhouLiver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Zi ChenThayer School of Engineering, Norris Cotton Cancer Center, Dartmouth College, Hanover, NH, USA.
Zhao-You TangLiver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, P.R. China.
Shanghai Sixth People's Hospital · CNFudan University · CNShanghai Xuhui Central Hospital · CNDartmouth College · USShanghai Tenth People's Hospital · CN

Funding

Epithelial layer jamming in breast cancer cell migrationU01CA202123 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2015 to 2019
$3.4M
NCI NIH HHS U01 CA202123
6 · The paper itself

Abstract

backgroundIncreasing amounts of evidence indicate that Missing in metastasis B (MIM-B) promotes cancer metastasis. Here, we sought to better understand the mechanism through which MIM-B promotes tumor metastasis in hepatocellular carcinoma (HCC).

methodsWe performed confocal microscopy analysis to determine the distributions of MIM-B and caveolin-1 and conducted co-immunoprecipitation assays to detect the interactions between MIM-B and caveolin-1

resultsWe found that MIM-B co-localizes with caveolin-1 and demonstrated that MIM-B and caveolin-1 interact

conclusionsMIM-B combined with caveolin-1 promotes metastasis of HCC, and elevated MIM-B and caveolin-1 expression levels are associated with a poor prognosis in HCC patients; therefore, MIM-B and caveolin-1 may represent novel targets for the diagnosis and treatment of HCC.

Indexed as

caveolin-1epidermal growth factor receptorhepatocellular carcinomametastasismissing in metastasis B

Identifiers

PMID29221140
PMCPMC5707034
OpenAlexW2751633074

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.