Evidence map›Paper›PMID 29221127›Full record

ArticleOncotarget2017

Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis.

Donghua Xu, Ye Jiang, Lu Yang, Xixing Hou, Jihong Wang, Weijun Gu, Xiaodong Wang, Lanyu Liu, Juan Zhang, Hongying Lu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  3. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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  11. Role of Liquid Biopsies in Rheumatoid Arthritis.Methods in molecular biology (Clifton, N.J.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Donghua Xu *Department of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Ye Jiang *Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lu Yang *Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xixing HouDepartment of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Jihong WangDepartment of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Weijun GuDepartment of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Xiaodong WangDepartment of Rheumatology and Immunology, The Affiliated Hospital of Weifang Medical University, Weifang 261000, China.
Lanyu LiuDepartment of Gynecology and Obstetrics, Weifang Hospital of Maternal and Child Health, Weifang 261000, Shandong Province, China.
Juan ZhangDepartment of Rehabilitation, Affiliated Huai'an Hospital of Xuzhou Medical College and Second People's Hospital of Huai'an, Huai'an 223001, China.
Hongying LuFunctional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang 261000, China.
Weifang Medical University · CNJiangsu Province Hospital · CNNanjing Medical University · CNWeifang Maternity and Child Care Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modifying effects of long noncoding RNAs (lncRNAs) in rheumatoid arthritis (RA) recently have drawn much attention; however, the underlying mechanisms remain largely unknown. Herein, we aim to investigate the expression profile of lncRNAs in RA and identify promising targets for RA diagnosis and treatment. Microarray screening and real-time PCR of lncRNAs were performed by use of serum samples from 3 RA patients and 3 healthy controls. Significantly differentially expressed lncRNAs were verified in serum samples from 43 RA patients and 40 healthy controls by real-time PCR. We found that there were 73 up-regulated and 61 down-regulated lncRNAs as well as 128 up-regulated and 37 down-regulated mRNAs in serum samples of RA patients. Validation in RA clinical samples indicated 5 of these lncRNAs were significantly up-regulated including RNA143598, RNA143596, HIX0032090, IGHCgamma1, and XLOC_002730. Significant association was observed between these lncRNAs and the disease course, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) as well as anti-cyclic citrullinated peptide (anti-CCP) antibody. Additionally, 55 of the differentially expressed mRNAs were associated with 41 lncRNAs and were involved in signaling pathways of toll like receptors (TLRs), nuclear factor-kappa B (NF-κB), and cytokine, especially the IRF3/IRF7 mediated signaling transduction. Our study firstly shows the specific profile of lncRNAs in the serum of RA patients and potential signaling pathways involved in RA pathogenesis, which may provide novel targets for the diagnosis and treatment of patients with RA.

Indexed as

long noncoding RNAsrheumatoid arthritistoll like receptor

Identifiers

PMID29221127
PMCPMC5707021
OpenAlexW2744067028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.