ArticleAnnals of neurology2018
Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
210 citing papers in PubMed, 8 syntheses or guidelines pooled it, 348 citations in OpenAlex.
- Associations between obstructive sleep apnea and Alzheimer's disease-related biomarkers (amyloid-β and tau) in blood and cerebrospinal fluid: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries.Aging clinical and experimental research · 2023Pooled it
- Shift work is significantly and positively associated with dementia: A meta-analysis study.Frontiers in public health · 2023Pooled it
- Cerebrospinal fluid orexin in Alzheimer's disease: a systematic review and meta-analysis.Sleep medicine · 2021Pooled it
- Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2020Pooled it
- Sleep Duration and Sleep Quality in Caregivers of Patients With Dementia: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Sleep architecture and self-reported sleep quality are associated with Alzheimer's disease biomarkers in older adults without dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Trial
- A Randomized Clinical Trial Reveals Effects of Mindfulness and Slow Breathing on Plasma Amyloid Beta Levels.Psychophysiology · 2025Trial
- Sleep deprivation and sleep intensity exert distinct effects on cerebral vasomotion and brain pulsations driven by the respiratory and cardiac cycles.PLoS biology · 2025Trial
- Sleep reduces CSF concentrations of beta-amyloid and tau: a randomized crossover study in healthy adults.Fluids and barriers of the CNS · 2025Trial
- Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment.GeroScience · 2024Trial
- A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease.Alzheimer's research & therapy · 2024Trial
- Trial
- A Randomized-Controlled Trial Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (REST).Journal of Alzheimer's disease : JAD · 2024Trial
- Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS.Annals of neurology · 2023Trial
- Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.Annals of neurology · 2020Trial
- Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men.Neurology · 2020Trial
150 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.