Evidence map›Paper›PMID 29220823›Full record

ArticleNeurobiology of aging2018

Patterns of progressive atrophy vary with age in Alzheimer's disease patients.

Cassidy M Fiford, Gerard R Ridgway, David M Cash, Marc Modat, Jennifer Nicholas, Emily N Manning, Ian B Malone, Geert Jan Biessels, Sebastien Ourselin, Owen T Carmichael and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Hippocampal grey matter changes across scales in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
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  11. Article
  12. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Age-at-Onset andNeurology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cassidy M FifordDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. Electronic address: cassidy.fiford.10@ucl.ac.uk.
Gerard R RidgwayFMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK.
David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Marc ModatDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Jennifer NicholasLondon School of Hygiene and Tropical Medicine, London, UK.
Emily N ManningDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Ian B MaloneDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Geert Jan BiesselsDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Sebastien OurselinDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Owen T CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, USA.
M Jorge CardosoDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK.
Josephine BarnesDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Medical Research Council MR/J014257/2Medical Research Council MR/M023664/1NIA NIH HHS U01 AG024904NIGMS NIH HHS U54 GM104940Wellcome TrustWellcome Trust 203145Z/16/Z
6 · The paper itself

Abstract

Age is not only the greatest risk factor for Alzheimer's disease (AD) but also a key modifier of disease presentation and progression. Here, we investigate how longitudinal atrophy patterns vary with age in mild cognitive impairment (MCI) and AD. Data comprised serial longitudinal 1.5-T magnetic resonance imaging scans from 153 AD, 339 MCI, and 191 control subjects. Voxel-wise maps of longitudinal volume change were obtained and aligned across subjects. Local volume change was then modeled in terms of diagnostic group and an interaction between group and age, adjusted for total intracranial volume, white-matter hyperintensity volume, and apolipoprotein E genotype. Results were significant at p < 0.05 with family-wise error correction for multiple comparisons. An age-by-group interaction revealed that younger AD patients had significantly faster atrophy rates in the bilateral precuneus, parietal, and superior temporal lobes. These results suggest younger AD patients have predominantly posterior progressive atrophy, unexplained by white-matter hyperintensity, apolipoprotein E, or total intracranial volume. Clinical trials may benefit from adapting outcome measures for patient groups with lower average ages, to capture progressive atrophy in posterior cortices.

Indexed as

AgedAgingAlzheimer DiseaseApolipoproteins EAtrophyCognitive DysfunctionDisease ProgressionFemaleGenotypeHippocampusHumansMagnetic Resonance AngiographyMaleOrgan SizeWhite MatterApolipoproteins EAgingAlzheimer's diseaseAtrophyEarly-onset Alzheimer's diseaseHippocampusLate-onsetMild cognitive impairment (MCI)

Identifiers

PMID29220823
PMCPMC5805840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.