Evidence map›Paper›PMID 29220676›Full record

ArticleAmerican journal of human genetics2017

Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution.

Arkan Abadi, Akram Alyass, Sebastien Robiou du Pont, Ben Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Diaz, James C Engert, Salim Yusuf, Hertzel C Gerstein and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Beyond predictive RAmerican journal of human genetics · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Natural selection and human adiposity: crafty genotype, thrifty phenotype.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  16. Article
  17. Article
  18. Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Arkan AbadiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.
Akram AlyassDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.
Sebastien Robiou du PontDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.
Ben BolkerDepartment of Mathematics and Statistics, McMaster University, Hamilton, ON L8S 4L8, Canada.
Pardeep SinghDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Viswanathan MohanMadras Diabetes Research Foundation, Gopalapuram, Chennai 600086, India.
Rafael DiazEstudios Clínicos Latino America, Paraguay 160, S2000CVD Rosario, Santa Fe, Argentina.
James C EngertMcGill University, Montreal, QC H3A 0G4, Canada.
Salim YusufDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Hertzel C GersteinDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Sonia S AnandDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada. Electronic address: meyred@mcmaster.ca.
Impact · CAMcMaster University · CAEstudios Clínicos Latinoamérica · ARHamilton General Hospital · CAMadras Diabetes Research Foundation · INMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression (MR) models. The effects of nine SNPs (24%)-rs1421085 (FTO; p = 8.69 × 10

Indexed as

Body Mass IndexPenetranceAdultAgedAged, 80 and overBody HeightGene-Environment InteractionGene FrequencyGenetic Predisposition to DiseaseHumansMiddle AgedMultifactorial InheritanceObesityPolymorphism, Single NucleotideQuantitative Trait LociWhite Peoplebody mass indexconditional quantile regressionepistasisgene-environment interactionsgene scoreheightmissing heritabilitypolygenic inheritancequantitative trait distributionvariable allele penetrance

Identifiers

PMID29220676
PMCPMC5812888
OpenAlexW2771845674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.