Evidence map›Paper›PMID 29220547›Full record

ArticleAlcoholism, clinical and experimental research2018

Impact of Moderate Alcohol Discontinuation on Insulin Action and Secretion in Latinos With and Without Hepatitis C.

Lindsay A Uribe, Peter Bacchetti, Nicholas Gelman, Esteban Burchard, Mark Fitch, Marc Hellerstein, Mandana Khalili

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01858012 (Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01858012 active not recruitingnot on this map

Impact of Hepatitis C on Insulin Sensitivity and Insulin Secretion in Latinos

TypeobservationalSponsorUniversity of California, San FranciscoRan2008 to 2026Enrolled250ConditionsInsulin ResistanceArmsModerate alcohol cessation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lindsay A UribeDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Peter BacchettiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Nicholas GelmanDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Esteban BurchardDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Mark FitchDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California.
Marc HellersteinDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California.
Mandana KhaliliDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-9178-9139
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
NCATS NIH HHS UL1 TR000004NIAAA NIH HHS K24 AA022523
6 · The paper itself

Abstract

backgroundInsulin resistance (IR) is associated with hepatitis C virus (HCV), and Latinos are both at risk of IR and are disproportionately affected by HCV. Moderate alcohol consumption improves insulin sensitivity and may modify HCV-associated IR. We investigated the impact of moderate alcohol discontinuation on insulin sensitivity and secretion in Latinos using direct measurements.

methodsTwenty-five nondiabetic, noncirrhotic Latino adults without (n = 17) or with (n = 8) HCV underwent 3-day metabolic assessment before and after prescription of 6 weeks of moderate alcohol discontinuation. Peripheral IR was measured via steady-state plasma glucose (SSPG) and hepatic IR using endogenous glucose production during a 2-step 240-minute insulin suppression test. Insulin secretion was measured using graded glucose infusion test.

resultsBaseline mean age was 46 ± 11 years, 63% male, 29% had HCV, and mean body mass index was 27 ± 4 kg/m

conclusionsShort-term moderate alcohol discontinuation adversely impacted hepatic IR in Latinos which was influenced by level of ALT at baseline independent of etiology. Although reduction in ALT through weight loss and HCV eradication remains a priority in improving IR, the observed nonharmful effect of moderate alcohol use represents a potentially confounding variable that warrants further study.

Indexed as

Alcohol AbstinenceHispanic or LatinoInsulin ResistanceInsulin SecretionAdultAlanine TransaminaseAlcohol DrinkingAspartate AminotransferasesFemaleHepatitis C, ChronicHumansInsulinMaleMiddle AgedAlanine TransaminaseAspartate AminotransferasesInsulinAlanine AminotransferaseHepatic Insulin ResistanceHepatitis C VirusHispanicInsulin Resistance

Identifiers

PMID29220547
PMCPMC5832577
OpenAlexW2773042913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.