ArticleMolecular biology and evolution2018
Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- Association of Chromosome 3p21.32 Haplotype Blocks Introgressed from Neanderthals with Critical COVID-19 in a Spanish Cohort.Life (Basel, Switzerland) · 2025Article
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Adaptive Introgression as an Evolutionary Force: A Meta-Analysis of Knowledge Trends.Evolutionary applications · 2025Article
- Standing genetic variation and introgression shape the cryptic radiation of Aquilegia in the mountains of Southwest China.Communications biology · 2025Article
- Secondary Contact, Introgressive Hybridization, and Genome Stabilization in Sticklebacks.Molecular biology and evolution · 2024Article
- More than a decade of genetic research on the Denisovans.Nature reviews. Genetics · 2024Review
- A Catalog of Coding Sequence Variations in Salivary Proteins' Genes Occurring during Recent Human Evolution.International journal of molecular sciences · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Article
- MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations.Molecular biology and evolution · 2023Article
- TNFRSF13B in B cell responses to organ transplantation.Human immunology · 2023Article
- Admixture has obscured signals of historical hard sweeps in humans.Nature ecology & evolution · 2022Article
- A need for standardized reporting of introgression: Insights from studies across eukaryotes.Evolution letters · 2022Article
- Chronology of natural selection in Oceanian genomes.iScience · 2022Article
- Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells.Molecular biology and evolution · 2022Article
- Underrepresented Populations at the Archaic Introgression Frontier.Frontiers in genetics · 2022Article
- The computational implementation of a platform of relative identity-by-descent scores algorithm for introgressive mapping.Frontiers in genetics · 2022Article
- Article
- The history and evolution of the Denisovan-Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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15 authors.
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Abstract
Recent studies have reported evidence suggesting that portions of contemporary human genomes introgressed from archaic hominin populations went to high frequencies due to positive selection. However, no study to date has specifically addressed the postintrogression population dynamics of these putative cases of adaptive introgression. Here, for the first time, we specifically define cases of immediate adaptive introgression (iAI) in which archaic haplotypes rose to high frequencies in humans as a result of a selective sweep that occurred shortly after the introgression event. We define these cases as distinct from instances of selection on standing introgressed variation (SI), in which an introgressed haplotype initially segregated neutrally and subsequently underwent positive selection. Using a geographically diverse data set, we report novel cases of selection on introgressed variation in living humans and shortlist among these cases those whose selective sweeps are more consistent with having been the product of iAI rather than SI. Many of these novel inferred iAI haplotypes have potential biological relevance, including three that contain immune-related genes in West Siberians, South Asians, and West Eurasians. Overall, our results suggest that iAI may not represent the full picture of positive selection on archaically introgressed haplotypes in humans and that more work needs to be done to analyze the role of SI in the archaic introgression landscape of living humans.
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