SynthesisPloS one2017
Does cognitive impairment impact adherence? A systematic review and meta-analysis of the association between cognitive impairment and medication non-adherence in stroke.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Factors Influencing Health Behavior Adherence in Young and Middle-Aged Stroke Patients.Revista de neurologia · 2026Observational
- The need for post-stroke cognitive screening - the rationale behind the Hungarian adaptation of the Oxford Cognitive Screen (OCS) and its pilot study.Cerebral circulation - cognition and behavior · 2026Article
- Illness acceptance and medication adherence in patients with diabetes in Poland: a cross-sectional study.Frontiers in public health · 2025Article
- Level of medication adherence and its determinants of cardiovascular disease patients attending at specialized teaching hospitals of Amhara regional state, Ethiopia: a multicenter cross-sectional study.Frontiers in pharmacology · 2024Article
- Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross-Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey.Journal of the American Heart Association · 2023Article
- Association of sleep duration and physical frailty with cognitive function in older patients with coexisting atrial fibrillation and heart failure.Nursing open · 2023Article
- Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation.European stroke journal · 2022Article
- Cognitive impairment, perceived medication adherence, and high-risk medication use in patients with reduced kidney function: A cross-sectional analysis.Health science reports · 2022Article
- The impact of poor medication knowledge on health-related quality of life in people with Parkinson's disease: a mediation analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Difficulties in reporting purpose and dosage of prescribed medications are associated with poor cognition and depression.PloS one · 2021Article
- Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia.BMC psychiatry · 2020Article
- Secondary Stroke Prevention After Ischemic Stroke in Patients with Alzheimer's Disease and Other Dementia Disorders.Journal of Alzheimer's disease : JAD · 2020Article
- Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease.Frontiers in neurology · 2020Article
- What Predicts Different Kinds of Nonadherent Behavior in Elderly People With Parkinson's Disease?Frontiers in medicine · 2020Article
- Cognitive Impairment Is Independently Associated with Non-Adherence to Antithrombotic Therapy in Older Patients with Atrial Fibrillation.International journal of environmental research and public health · 2019Article
- Impact of psychiatric comorbidity on the severity, short-term functional outcome, and psychiatric complications after acute stroke.Neuropsychiatric disease and treatment · 2019Article
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort.PloS one · 2019Article
- Psychosocial and Neurocognitive Factors Associated With Hepatitis C - Implications for Future Health and Wellbeing.Frontiers in psychology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile medication adherence is essential for the secondary prevention of stroke, it is often sub-optimal, and can be compromised by cognitive impairment. This study aimed to systematically review and meta-analyse the association between cognitive impairment and medication non-adherence in stroke.
methodsA systematic literature search of longitudinal and cross-sectional studies of adults with any stroke type, which reported on the association between any measure of non-adherence and cognitive impairment, was carried out according to PRISMA guidelines. Odds ratios and 95% confidence intervals were the primary measure of effect. Risk of bias was assessed using the Cochrane Bias Methods Group's Tool to Assess Risk of Bias in Cohort Studies, with evidence quality assessed according to the GRADE approach. We conducted sensitivity analyses according to measure of cognitive impairment, measure of medication adherence, population, risk of bias and adjustment for covariates. The protocol was registered with PROSPERO.
resultsFrom 1,760 titles and abstracts, we identified 9 studies for inclusion. Measures of cognitive impairment varied from dementia diagnosis to standardised cognitive assessments. Medication adherence was assessed through self-report or administrative databases. The majority of studies were of medium risk of bias (n = 6); two studies had low risk of bias. Findings were mixed; when all studies were pooled, there was no evidence of an association between cognitive impairment and medication non-adherence post-stroke [OR (95% CI): 0.85 (0.66, 1.03)]. However, heterogeneity was substantial [I2 = 90.9%, p < .001], and the overall evidence quality was low.
conclusionsFew studies have explored associations between cognitive impairment and medication adherence post-stroke, with substantial heterogeneity in study populations, and definitions and assessments of non-adherence and cognitive impairment. Further research using clear, standardised and objective assessments is needed to clarify the association between cognitive impairment and medication non-adherence in stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.