ReviewAnnals of the American Thoracic Society2018
A Practical Approach to Severe Asthma in Children.
Review in Annals of the American Thoracic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Effects of mesenchymal stromal cell-conditioned media on measures of lung structure and function: a systematic review and meta-analysis of preclinical studies.Stem cell research & therapy · 2020Pooled it
- Current Practices and Variations Among Pediatric Severe Asthma Programs in the United States-The North American Severe Pediatric Asthma Consortium.Pediatric pulmonology · 2026Observational
- Marked Variation in Paediatric Problematic Severe Asthma Services Across Australia and New Zealand.Journal of paediatrics and child health · 2025Observational
- Eosinophilia and wheeze: thinking beyond asthma.Breathe (Sheffield, England) · 2024Article
- Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Asthmatic Children: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Biologic Therapies in Pediatric Asthma.Journal of personalized medicine · 2022Review
- Severe asthma in children: Description of a large multidisciplinary clinical cohort.Pediatric pulmonology · 2022Article
- Association of mold levels in urban children's homes with difficult-to-control asthma.The Journal of allergy and clinical immunology · 2022Article
- Severe asthma in children: An official statement from Saudi Pediatric Pulmonology Association.Saudi medical journal · 2022Article
- Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary.Clinical reviews in allergy & immunology · 2022Review
- Analysis of the Consumption of Drugs Prescribed for the Treatment of Asthma in Belgian Children.International journal of environmental research and public health · 2022Article
- Defining pediatric asthma: phenotypes to endotypes and beyond.Pediatric research · 2021Review
- Asthma control and psychological health in pediatric severe asthma.Pediatric pulmonology · 2021Article
- Difficult and Severe Asthma in Children.Children (Basel, Switzerland) · 2020Review
- Adjuvant treatment with Xiaoqinglong formula for bronchial asthma: Protocol of systematic review and meta-analysis.Medicine · 2019Article
- Expression of corticosteroid-regulated genes by PBMCs in children with asthma.The Journal of allergy and clinical immunology · 2019Article
- Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma?Frontiers in pediatrics · 2019Review
- Current State and Future of Biologic Therapies in the Treatment of Asthma in Children.Pediatric allergy, immunology, and pulmonology · 2018Review
- Erratum: A Practical Approach to Severe Asthma in Children.Annals of the American Thoracic Society · 2018Article
- New Drugs for Pediatric Asthma.Frontiers in pediatrics · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Severe asthma accounts for only a small proportion of the children with asthma but a disproportionately high amount of resource utilization and morbidity. It is a heterogeneous entity and requires a step-wise, evidence-based approach to evaluation and management by pediatric subspecialists. The first step is to confirm the diagnosis by eliciting confirmatory history and objective evidence of asthma and excluding possible masquerading diagnoses. The next step is to differentiate difficult-to-treat asthma, asthma that can be controlled with appropriate management, from asthma that requires the highest level of therapy to maintain control or remains uncontrolled despite management optimization. Evaluation of difficult-to-treat asthma includes an assessment of medication delivery, the home environment, and, if possible, the school and other frequented locations, the psychosocial situation, and comorbid conditions. Once identified, aggressive management of issues related to poor adherence and drug delivery, remediation of environmental triggers, and treatment of comorbid conditions is necessary to characterize the degree of control that can be achieved with standard therapies. For the small proportion of patients whose disease remains poorly controlled with these interventions, the clinician may assess steroid responsiveness and determine the inflammatory pattern and eligibility for biologic therapies. Management of severe asthma refractory to traditional therapies involves considering the various biologic and other newly approved treatments as well as emerging therapies based on the individual patient characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.