Evidence map›Paper›PMID 29219950›Full record

ReviewActa pharmacologica Sinica2018

Exosomes: new molecular targets of diseases.

Saheli Samanta, Sheeja Rajasingh, Nicholas Drosos, Zhigang Zhou, Buddhadeb Dawn, Johnson Rajasingh

Abstract readReview
In one paragraph

Review in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

241 citing papers in PubMed.

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  15. Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation.American journal of physiology. Heart and circulatory physiology · 2025
    Review
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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saheli SamantaCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.
Sheeja RajasinghCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.
Nicholas DrososCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.
Zhigang ZhouCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.
Buddhadeb DawnCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.
Johnson RajasinghCardiovascular Research Institute, Division of Cardiovascular Diseases, Department of Internal Medicine.

Funding

Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
NIGMS NIH HHS P20 GM104936
6 · The paper itself

Abstract

Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased states. EVs contain natural cargo molecules, such as miRNA, mRNA and proteins, and transfer these functional cargos to neighboring cells or more distant cells through circulation. These functionally active molecules then affect distinct signaling cascades. The message conveyed to the recipient cells is dependent upon the composition of the EV, which is determined by the parent cell and the EV biogenesis. Because of their properties such as increased stability in circulation, biocompatibility, low immunogenicity and toxicity, EVs have drawn attention as attractive delivery systems for therapeutics. This review focuses on the functional use of exosomes in therapy and the potential advantages and challenges in using exosomes for therapeutic purposes.

Indexed as

AnimalsDrug CarriersEnzyme InhibitorsExosomesGene Transfer TechniquesHeart DiseasesHumansInflammationLiver DiseasesNeoplasmsNeurodegenerative DiseasesDrug CarriersEnzyme Inhibitors

Identifiers

PMID29219950
PMCPMC5888687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.