ArticleAnnals of the American Thoracic Society2018
Prenatal and Early Life Fructose, Fructose-Containing Beverages, and Midchildhood Asthma.
Article in Annals of the American Thoracic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Fructose-Containing Dietary Exposures and Pediatric Atopic Disease: A Review of Epidemiologic Evidence.Nutrients · 2026Pooled it
- Dietary intake of different carbohydrate types and asthma risk: a systematic review and meta-analysis.Nutrition journal · 2025Pooled it
- A systematic review and meta-analysis of the association of all types of beverages high in fructose with asthma in children and adolescents.BMC nutrition · 2024Pooled it
- Association between soft drinks consumption and asthma: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Low glycaemic index diet in pregnancy and child asthma: follow-up of the ROLO trial.The British journal of nutrition · 2026Trial
- Dietary sugar and soft drink consumption in relation to atopic disease in children: evidence from the Polish global asthma network study.BMC pulmonary medicine · 2026Article
- Associations Between the Maternal Diet Index and Childhood Asthma: The NorthPop and Healthy Start Cohorts.Clinical and translational allergy · 2025Article
- Ultra-Processed Foods and Respiratory and Allergic Diseases in Childhood: Epidemiological Evidence and Mechanistic Insights.Nutrients · 2025Review
- Associations of Infant Colic and Excessive Crying With Atopic Outcomes in Childhood and Adolescence.The Journal of pediatrics · 2025Article
- Disproportionately higher asthma risk and incidence with high fructose corn syrup, but not sucrose intake, among Black young adults: the CARDIA Study.Public health nutrition · 2025Article
- The UK Soft Drinks Industry Levy and childhood hospital admissions for asthma in England.Nature communications · 2024Article
- The influence of maternal diet on offspring's gut microbiota in early life.Archives of gynecology and obstetrics · 2024Review
- The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity.Nutrients · 2024Review
- Dietary intake, antioxidants, minerals and vitamins in relation to childhood asthma: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Assessing sugar-sweetened beverage consumption in early pregnancy using a substance abuse framework.Scientific reports · 2023Article
- Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.The Journal of nutritional biochemistry · 2023Article
- Review
- The association of pure fruit juice, sugar-sweetened beverages and fruit consumption with asthma prevalence in adolescents growing up from 11 to 20 years: The PIAMA birth cohort study.Preventive medicine reports · 2022Article
- Factors Associated with Beverage Intake in Low-Income, Overweight, or Obese Pregnant Women.Nutrients · 2022Article
- Examining Lifestyle Components in Hospitalized COVID-19 Patients, Iran 2021.Journal of lifestyle medicine · 2022Article
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5 authors.
Funding
Abstract
rationaleCross-sectional studies have linked intake of high-fructose corn syrup-sweetened beverages with asthma in schoolchildren.
objectivesTo examine associations of maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose with current asthma in midchildhood (median age, 7.7 yr).
methodsWe assessed maternal pregnancy (first- and second-trimester average) and child (median age, 3.3 yr) intake of sugar-sweetened beverages and total fructose using food frequency questionnaires in 1,068 mother-child pairs from Project Viva, a prospective prebirth cohort. In a multivariable analysis, we examined associations of quartiles of maternal and child sugar-sweetened beverage, juice, and total fructose intake with child current asthma in midchildhood, assessed by questionnaire as ever having doctor-diagnosed asthma plus taking asthma medications or reporting wheezing in the past 12 months.
resultsHigher maternal pregnancy sugar-sweetened beverage consumption (mean, 0.6 servings/d; range, 0-5) was associated with younger maternal age, nonwhite race/ethnicity, lower education and income, and higher prepregnancy body mass index. Adjusting for prepregnancy body mass index and other covariates, comparing quartile 4 with quartile 1, higher maternal pregnancy intake of sugar-sweetened beverages (odds ratio, 1.70; 95% confidence interval, 1.08-2.67) and total fructose (odds ratio, 1.58; 95% confidence interval, 0.98-2.53) were associated with greater odds of midchildhood current asthma (prevalence, 19%). Higher early childhood fructose intake (quartile 4 vs. quartile 1) was also associated with midchildhood current asthma in models adjusted for maternal sugar-sweetened beverages (odds ratio, 1.79; 95% confidence interval, 1.07-2.97) and after additional adjustment for midchildhood body mass index z-score (odds ratio, 1.77; 95% confidence interval, 1.06-2.95).
conclusionsHigher sugar-sweetened beverage and fructose intake during pregnancy and in early childhood was associated with childhood asthma development independent of adiposity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.