Evidence map›Paper›PMID 29219598›Full record

ArticlePhysical review letters2017

Nucleation of Multiple Buckled Structures in Intertwined DNA Double Helices.

Sumitabha Brahmachari, Kathryn H Gunn, Rebecca D Giuntoli, Alfonso Mondragón, John F Marko

Open access · greenAbstract read
In one paragraph

Article in Physical review letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. DNA Mechanics and Topology.Advances in experimental medicine and biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sumitabha BrahmachariDepartment of Physics and Astronomy, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Kathryn H GunnDepartment of Physics and Astronomy, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Rebecca D GiuntoliDepartment of Physics and Astronomy, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Alfonso MondragónDepartment of Physics and Astronomy, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
John F MarkoDepartment of Physics and Astronomy, and Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Northwestern University · US

Funding

Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2015 to 2019
$14.9M
Spatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V · 2015 to 2020
$10.4M
Structural and biophysical studies of proteins, nucleic acids, and their complexesR35GM118108 · NIGMS · NORTHWESTERN UNIVERSITY · PI Alfonso Mondragon · 2017 to 2026
$5.4M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
STRUCTURE/FUNCTION STUDIES OF TYPE I TOPOISOMERASESR01GM051350 · NIGMS · NORTHWESTERN UNIVERSITY · PI MONDRAGON, ALFONSO · 1994 to 2017
$3.9M
Activities of nucleoprotein complexes visualized in single-molecule experimentsR01GM105847 · NIGMS · NORTHWESTERN UNIVERSITY · PI MARKO, JOHN F · 2013 to 2025
$2.5M
NCI NIH HHS U54 CA193419NIDDK NIH HHS U54 DK107980NIGMS NIH HHS R01 GM051350NIGMS NIH HHS R01 GM105847NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

We study the statistical-mechanical properties of intertwined double-helical DNAs (DNA braids). In magnetic tweezers experiments, we find that torsionally stressed stretched braids supercoil via an abrupt buckling transition, which is associated with the nucleation of a braid end loop, and that the buckled braid is characterized by a proliferation of multiple domains. Differences between the mechanics of DNA braids and supercoiled single DNAs can be understood as an effect of the increased bulkiness in the structure of the former. The experimental results are in accord with the predictions of a statistical-mechanical model.

Indexed as

Nucleic Acid ConformationDNADNA, SuperhelicalMagneticsDNADNA, Superhelical

Identifiers

PMID29219598
PMCPMC5726782
OpenAlexW2949228130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.