ArticleThe Laryngoscope2018
Improved adductor function after canine recurrent laryngeal nerve injury and repair using muscle progenitor cells.
Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Novel Biomolecule-Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury.The Laryngoscope · 2025Article
- Neuromuscular junction visualization in paraffin-embedded thyroarytenoid muscle sections: Expanding options beyond frozen section analysis.Laryngoscope investigative otolaryngology · 2025Article
- Optimizing transport methods to preserve function of self-innervating muscle cells for laryngeal injection.Laryngoscope investigative otolaryngology · 2024Article
- Tissue-Engineered Implant for Hemilaryngectomy Reconstruction with Recurrent Laryngeal Nerve Injury.The Laryngoscope · 2024Article
- Early Changes in Porcine Larynges Following Injection of Motor-Endplate Expressing Muscle Cells for the Treatment of Unilateral Vocal Fold Paralysis.The Laryngoscope · 2024Article
- Augmentation and vocal fold biomechanics in a recurrent laryngeal nerve injury model.Laryngoscope investigative otolaryngology · 2022Article
- A narrative review of current therapies in unilateral recurrent laryngeal nerve injury caused by thyroid surgery.Gland surgery · 2022Review
- Laryngeal Reconstruction Using Tissue-Engineered Implants in Pigs: A Pilot Study.The Laryngoscope · 2021Article
- Stem cell treatments for oropharyngeal dysphagia: Rationale, benefits, and challenges.World journal of stem cells · 2020Review
- Laryngeal adductor function following potassium titanyl phosphate laser welding of the recurrent laryngeal nerve.The Laryngoscope · 2020Article
- Motor endplate-expressing cartilage-muscle implants for reconstruction of a denervated hemilarynx.The Laryngoscope · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMuscle progenitor cells (MPCs) can be isolated from muscle samples and grown to a critical mass in culture. They have been shown to survive and integrate when implanted into rat laryngeal muscles. In this study, the ability of MPC implants to enhance adductor function of reinnervated thyroarytenoid muscles was tested in a canine model. STUDY
designAnimal study.
methodsSternocleidomastoid muscle samples were harvested from three canines. Muscle progenitor cells were isolated and cultured to 10
resultsMuscle progenitor cells were successfully cultured from all dogs. Laryngeal adductor force measurements averaged 60% of their baseline pretreatment values in nonimplanted controls, 98% after implantation with MPCs, and 128% after implantation with motor endplate-enhanced MPCs. Histology confirmed that the implanted MPCs survived, became integrated into thyroarytenoid muscle fibers, and were in close contact with nerve endings, suggesting functional innervation.
conclusionMuscle progenitor cells were shown to significantly enhance adductor function in this pilot canine study. Patient-specific MPC implantation could potentially be used to improve laryngeal function in patients with vocal fold paresis/paralysis, atrophy, and other conditions. Further experiments are planned. LEVEL OF EVIDENCE: NA. Laryngoscope, 2017.
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Registered trials
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