ArticleJournal of neural engineering2018
Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.
Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 38 citations in OpenAlex.
- Chronic alteration of CaBiomaterials · 2026Article
- Lipid nanoparticle-mediated Cd14 siRNA delivery ameliorates the acute inflammatory response to intracortical microelectrode implantation.Acta biomaterialia · 2026Article
- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Corrigendum to "Platelets and Hemostatic Proteins are Co-Localized with Chronic Neuroinflammation Surrounding Implanted Intracortical Microelectrodes" [Acta Biomaterialia. Volume 166, August 2023, Pages 278-290].Acta biomaterialia · 2024Article
- In Vivo Characterization of Intracortical Probes with Focused Ion Beam-Etched Nanopatterned Topographies.Micromachines · 2024Article
- A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice.Alzheimer's research & therapy · 2023Article
- Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance.Micromachines · 2023Article
- Differential expression of genes involved in the chronic response to intracortical microelectrodes.Acta biomaterialia · 2023Article
- Platelets and hemostatic proteins are co-localized with chronic neuroinflammation surrounding implanted intracortical microelectrodes.Acta biomaterialia · 2023Article
- Activation of inflammasomes and their effects on neuroinflammation at the microelectrode-tissue interface in intracortical implants.Biomaterials · 2023Article
- Advancing the interfacing performances of chronically implantable neural probes in the era of CMOS neuroelectronics.Frontiers in neuroscience · 2023Review
- Article
- Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications.Frontiers in neuroscience · 2021Article
- Investigating the Association between Motor Function, Neuroinflammation, and Recording Metrics in the Performance of Intracortical Microelectrode Implanted in Motor Cortex.Micromachines · 2020Article
- Differential expression of genes involved in the acute innate immune response to intracortical microelectrodes.Acta biomaterialia · 2020Article
- Toward Standardization of Electrophysiology and Computational Tissue Strain in Rodent Intracortical Microelectrode Models.Frontiers in bioengineering and biotechnology · 2020Article
- A graphical user interface to assess the neuroinflammatory response to intracortical microelectrodes.Journal of neuroscience methods · 2019Article
- Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes.Frontiers in neuroscience · 2019Review
- Insights From Dynamic Neuro-Immune Imaging on Murine Immune Responses to CNS Damage.Frontiers in neuroscience · 2019Review
Corrections and comments
- Erratum issuedErratum.2018
Authors and funding
18 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveNeuroinflammatory mechanisms are hypothesized to contribute to intracortical microelectrode failures. The cluster of differentiation 14 (CD14) molecule is an innate immunity receptor involved in the recognition of pathogens and tissue damage to promote inflammation. The goal of the study was to investigate the effect of CD14 inhibition on intracortical microelectrode recording performance and tissue integration. APPROACH: Mice implanted with intracortical microelectrodes in the motor cortex underwent electrophysiological characterization for 16 weeks, followed by endpoint histology. Three conditions were examined: (1) wildtype control mice, (2) knockout mice lacking CD14, and (3) wildtype control mice administered a small molecule inhibitor to CD14 called IAXO-101. MAIN
resultsThe CD14 knockout mice exhibited acute but not chronic improvements in intracortical microelectrode performance without significant differences in endpoint histology. Mice receiving IAXO-101 exhibited significant improvements in recording performance over the entire 16 week duration without significant differences in endpoint histology. SIGNIFICANCE: Full removal of CD14 is beneficial at acute time ranges, but limited CD14 signaling is beneficial at chronic time ranges. Innate immunity receptor inhibition strategies have the potential to improve long-term intracortical microelectrode performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.