Evidence map›Paper›PMID 29218998›Full record

ArticleFuture cardiology2018

VKORC1-1639A allele influences warfarin maintenance dosage among Blacks receiving warfarin anticoagulation: a retrospective cohort study.

Fatima Donia Mili, Tenecia Allen, Paula Weinstein Wadell, W Craig Hooper, Christine De Staercke, Christopher J Bean, Cathy Lally, Harland Austin, Nanette K Wenger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Oral Anticoagulant Therapy-When Art Meets Science.Journal of clinical medicine · 2019
    Review
  2. Polymorphisms ofThe application of clinical genetics · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fatima Donia MiliHemostasis Laboratory Branch, Division of Blood Disorders, Centers for Disease Control & Prevention, Atlanta, GA 30329, USA.
Tenecia AllenEmory Heart & Vascular Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
Paula Weinstein WadellHemostasis Laboratory Branch, Division of Blood Disorders, Centers for Disease Control & Prevention, Atlanta, GA 30329, USA.
W Craig HooperHemostasis Laboratory Branch, Division of Blood Disorders, Centers for Disease Control & Prevention, Atlanta, GA 30329, USA.
Christine De StaerckeHemostasis Laboratory Branch, Division of Blood Disorders, Centers for Disease Control & Prevention, Atlanta, GA 30329, USA.
Christopher J BeanHemostasis Laboratory Branch, Division of Blood Disorders, Centers for Disease Control & Prevention, Atlanta, GA 30329, USA.
Cathy LallyDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA.
Harland AustinDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA.
Nanette K WengerEmory Heart & Vascular Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
Centers for Disease Control and Prevention · USEmory University · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

aimThe study objectives were to investigate the association between selected CYP2C9 and VKORC1 single nucleotide polymorphisms with serious bleeding or thrombotic risk, and to estimate mean daily maintenance dose of warfarin and international normalized ratio measurements among Blacks receiving warfarin anticoagulation.

methodsWe conducted a retrospective cohort study among 230 Black adults receiving warfarin for a minimum of three consecutive months with a confirmed date of first dosage.

resultsA lower mean daily maintenance dosage of warfarin was required to maintain an international normalized ratio measurement within the therapeutic range among Blacks with the VKORC1-1639G>A variant alleles ([G/A vs G/G, p = 0.02], [A/A vs G/A, p = 0.008] and [A/A vs G/G, p = 0.001]).

conclusionData indicated that VKORC1-1639A variant allele influenced warfarin daily maintenance dosage among our small, likely admixed Black patient population.

Indexed as

Black or African AmericanPolymorphism, Single NucleotideAllelesAnticoagulantsDose-Response Relationship, DrugFemaleFollow-Up StudiesGenotypeGeorgiaHumansIncidenceMaleMiddle AgedPolymerase Chain ReactionRetrospective StudiesThrombosisAnticoagulantsVitamin K Epoxide ReductasesVKORC1 protein, humanWarfarinanticoagulationBlacksCYP2C9pharmacogeneticsthromboembolismVKORC1VKORC1-1639G>A warfarin

Identifiers

PMID29218998
PMCPMC6727961
OpenAlexW2774001566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.