SynthesisPediatric transplantation2018
A systematic review of immunosuppressant adherence interventions in transplant recipients: Decoding the streetlight effect.
Synthesis in Pediatric transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Adherence to immunosuppression in adult heart transplant recipients: A systematic review.Transplantation reviews (Orlando, Fla.) · 2021Pooled it
- A remote intervention to improve medication nonadherence guided by a marker of risk derived from the electronic health records of adolescent transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Trial
- Video Education and Behavior Contract to Improve Outcomes After Renal Transplantation (VECTOR): A Randomized Controlled Trial.Patient preference and adherence · 2024Trial
- The Palliation of Pediatric Kidney Transplantation.Pediatric transplantation · 2026Review
- Psychosocial challenges faced by children who had a solid organ transplant: adherence, transition, and posttraumatic stress.Current opinion in organ transplantation · 2026Review
- Assessment of Readiness for Discharge and Its Psychosocial Determinants in Kidney and Liver Transplant Patients in Poland-A Cross-Sectional Analytical Study.Healthcare (Basel, Switzerland) · 2025Article
- Child and adolescent heart and lung post-transplant adherence.JHLT open · 2025Article
- Epidemiology and Risk Prediction Model of Multidrug-Resistant Organism Infections After Liver Transplant Recipients: A Single-Center Cohort Study.Bioengineering (Basel, Switzerland) · 2025Article
- Intrapatient tacrolimus variability is associated with medical nonadherence among pediatric kidney transplant recipients.Frontiers in transplantation · 2025Article
- Cardiovascular Precision Medicine and Remote Intervention Trial Rationale and Design.Journal of clinical medicine · 2024Article
- Changes in Medication Adherence Across the Posttransplant Period in Pediatric Organ Transplant Recipients.Clinical transplantation · 2024Article
- Patient Engagement and Medication Consistency with Adolescent Heart Transplant Recipients.Proceedings. IEEE International Conference on Healthcare Informatics · 2024Article
- Electronic health record-enabled routine assessment of medication adherence after solid organ transplantation: the time is now.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Demographic Factors, Medication Adherence, and Post-transplant Health Outcomes: A Longitudinal Multilevel Modeling Approach.Journal of clinical psychology in medical settings · 2024Article
- The improving Medication Adherence in Adolescents and young adults following Liver Transplantation (iMALT) multisite trial: Design and trial implementation considerations.Clinical trials (London, England) · 2023Article
- Improving adherence to immunosuppression after liver or kidney transplantation in individuals with impairments in personality functioning - A randomized controlled single center feasibility study.Frontiers in psychology · 2023Article
- Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment.Materials today. Bio · 2022Article
- An mHealth App to Promote Adherence to Immunosuppressant Medication and Track Symptoms in Children After Hematopoietic Stem Cell Transplant: Protocol for a Mixed Methods Usability Study.JMIR research protocols · 2022Article
- Detecting, preventing and treating non-adherence to immunosuppression after kidney transplantation.Clinical kidney journal · 2022Review
- Posttraumatic stress and medication adherence in pediatric transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Non-adherence to immunosuppressant medications is an important risk factor for graft dysfunction. To evaluate the effectiveness of adherence-enhancing interventions, we reviewed adherence intervention studies in solid organ transplant recipients (all ages). Using the following databases: PsycINFO, PubMed, Scopus, and ScienceDirect, we identified 41 eligible studies. Only three non-randomized trials showed a possible positive effect on objective indicators of transplant outcomes (such as rejection, liver enzyme levels, kidney function). None of the 21 RCTs showed an improvement in transplant outcomes. Three studies showed a higher rate of adverse events in the intervention group as compared with controls, although this may be related to ascertainment bias. Improvement in adherence as measured indirectly (eg, with electronic monitoring devices) was not aligned with effects on transplant outcomes. We conclude that adherence interventions, to date, have largely been ineffective in improving transplant outcomes. To improve this track record, intervention efforts may wish to concentrate on non-adherent patients (rather than use convenience sampling, which excludes many of the patients who need the intervention), use direct measures of adherence to guide the interventions, and employ strategies that are intensive and yet engaging enough to ensure that non-adherent patients are able to participate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.