ArticleThe Journal of comparative neurology2018
Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.
Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice.Autism research : official journal of the International Society for Autism Research · 2026Article
- Hypoactivity, abnormal development of dendrites relevant to impaired synaptic transmission of calretinin-expressing interneurons in the medial prefrontal cortex underlies social deficits of mouse model in autism.Translational psychiatry · 2026Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System.Physiology (Bethesda, Md.) · 2024Review
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice.Brain structure & function · 2021Article
- Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon.Cell reports · 2021Article
- Some animal models are more equal than others: Cortico-striatal circuits for translation.Lab animal · 2020Article
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry.The European journal of neuroscience · 2019Review
- Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.The Journal of comparative neurology · 2018Article
- Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018.Frontiers in neuroanatomy · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Calretinin-expressing (CR+) interneurons are the most common type of striatal interneuron in primates. However, because CR+ interneurons are relatively scarce in rodent striatum, little is known about their molecular and other properties, and they are typically excluded from models of striatal circuitry. Moreover, CR+ interneurons are often treated in models as a single homogenous population, despite previous descriptions of their heterogeneous structures and spatial distributions in rodents and primates. Here, we demonstrate that, in rodents, the combinatorial expression of secretagogin (Scgn), specificity protein 8 (SP8) and/or LIM homeobox protein 7 (Lhx7) separates striatal CR+ interneurons into three structurally and topographically distinct cell populations. The CR+/Scgn+/SP8+/Lhx7- interneurons are small-sized (typically 7-11 µm in somatic diameter), possess tortuous, partially spiny dendrites, and are rostrally biased in their positioning within striatum. The CR+/Scgn-/SP8-/Lhx7- interneurons are medium-sized (typically 12-15 µm), have bipolar dendrites, and are homogenously distributed throughout striatum. The CR+/Scgn-/SP8-/Lhx7+ interneurons are relatively large-sized (typically 12-20 µm), and have thick, infrequently branching dendrites. Furthermore, we provide the first in vivo electrophysiological recordings of identified CR+ interneurons, all of which were the CR+/Scgn-/SP8-/Lhx7- cell type. In the primate striatum, Scgn co-expression also identified a topographically distinct CR+ interneuron population with a rostral bias similar to that seen in both rats and mice. Taken together, these results suggest that striatal CR+ interneurons comprise at least three molecularly, structurally, and topographically distinct cell populations in rodents. These properties are partially conserved in primates, in which the relative abundance of CR+ interneurons suggests that they play a critical role in striatal microcircuits.
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