Evidence map›Paper›PMID 29218725›Full record

ArticleThe Journal of comparative neurology2018

Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.

Nadia Parmhans, Szilard Sajgo, Jingwen Niu, Wenqin Luo, Tudor Constantin Badea

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nadia ParmhansRetinal Circuit Development & Genetics Unit, Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland.
Szilard SajgoRetinal Circuit Development & Genetics Unit, Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland.ORCID 0000-0002-5290-2298
Jingwen NiuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Tudor Constantin BadeaRetinal Circuit Development & Genetics Unit, Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland.ORCID 0000-0003-3086-6713
National Eye Institute · USUniversity of Pennsylvania · US

Funding

Retinal Circuit Development & GeneticsZIAEY000504 · NEI · NATIONAL EYE INSTITUTE · PI BADEA, TUDOR · 2011 to 2021
$15.6M
Molecular mechanisms in controlling development of touch-sensing neuronsR01NS083702 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2013 to 2022
$4.1M
Intramural NIH HHS ZIA EY000504NINDS NIH HHS R01 NS083702
6 · The paper itself

Abstract

We report the retinal expression pattern of Ret, a receptor tyrosine kinase for the glial derived neurotrophic factor (GDNF) family ligands (GFLs), during development and in the adult mouse. Ret is initially expressed in retinal ganglion cells (RGCs), followed by horizontal cells (HCs) and amacrine cells (ACs), beginning with the early stages of postmitotic development. Ret expression persists in all three classes of neurons in the adult. Using RNA sequencing, immunostaining and random sparse recombination, we show that Ret is expressed in at least three distinct types of ACs, and ten types of RGCs. Using intersectional genetics, we describe the dendritic arbor morphologies of RGC types expressing Ret in combination with each of the three members of the POU4f/Brn3 family of transcription factors. Ret expression overlaps with Brn3a in 4 RGC types, with Brn3b in 5 RGC types, and with Brn3c in one RGC type, respectively. Ret

Indexed as

Amacrine CellsAnimalsDendritesGene Expression ProfilingGene Expression Regulation, DevelopmentalImmunohistochemistryMice, TransgenicProto-Oncogene Proteins c-retRetinal Ganglion CellsRetinal Horizontal CellsTranscription Factor Brn-3AVisual PathwaysPou4f1 protein, mouseProto-Oncogene Proteins c-retRet protein, mouseTranscription Factor Brn-3Aamacrine cellBrn3aBrn3bBrn3chorizontal celllateral geniculate nucleusneurotrophinPou4fRetretinal ganglion cellsuperior colliculustranscription

Identifiers

PMID29218725
PMCPMC6201275
OpenAlexW2773064559

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.