Evidence map›Paper›PMID 29218660›Full record

ArticleSurgical endoscopy2018

How bariatric surgery affects liver volume and fat density in NAFLD patients.

Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Laparoscopic sleeve gastrectomy altersScientific reports · 2021
    Trial
  4. Review
  5. Article
  6. Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Towards precision medicine in bariatric surgery prescription.Reviews in endocrine & metabolic disorders · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. ACCURACY OF ELASTOGRAPHY IN THE ASSESSMENT OF REDUCTION IN LIVER STEATOSIS AND FIBROSIS IN THE EARLY POSTOPERATIVE PERIOD AFTER BARIATRIC SURGERY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ran B LuoDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA. r4luo@ucsd.edu.
Toshiaki SuzukiDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA.
Jonathan C HookerLiver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Yesenia CovarrubiasLiver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Alexandra SchleinLiver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Shanglei LiuDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA.
Jeffrey B SchwimmerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Scott B ReederDepartments of Radiology, Medical Physics, Biomedical Engineering, Medicine and Emergency Medicine, University of Wisconsin, Wisconsin, MI, USA.
Luke M FunkDepartment of Surgery, University of Wisconsin, Madison, WI, USA.
Jacob A GreenbergDepartment of Surgery, University of Wisconsin, Madison, WI, USA.
Guilherme M CamposDivision of Bariatric and GI Surgery, Virginia Commonwealth University, Richmond, VA, USA.
Bryan J SandlerDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA.
Santiago HorganDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, USA.
Garth R JacobsenDivision of Minimally Invasive Surgery, Department of Surgery, University of California, San Diego, 9500 Gilman Drive MC 0740, San Diego, CA, 92093, USA.
University of California, San Diego · USUniversity of Wisconsin–Madison · USRady Children's Hospital-San Diego · USVirginia Commonwealth University · US

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017
$2.7M
Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013
$1.2M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK100651NIH HHS K24DK102595NIH HHS R01DK083380NIH HHS R01DK088925NIH HHS R01DK100651
6 · The paper itself

Abstract

introductionNonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND

methodsThis was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months. Liver volumes and proton-density fat fraction (PDFF) were calculated from offline MRI images. Primary outcomes were changes in weight, body mass index (BMI), percent excess weight loss (EWL%), liver volume, and PDFF. Resolution of steatosis, as defined as PDFF < 6.4% based on previously published cutoffs, was assessed. Secondarily, outcomes were compared between patients who underwent laparoscopic sleeve gastrectomy (LSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB).

resultsFrom October 2010 to June 2015, 124 patients were recruited. 49 patients (39.5%) completed all five scans. EWL% at 6 months was 55.6 ± 19.0%. BMI decreased from 45.3 ± 5.9 to 34.4 ± 5.1 kg/m

conclusionPatients with NAFLD undergoing bariatric surgery can expect significant decreases in liver volume and hepatic steatosis at 6 months, with 83.7% of patients achieving resolution of steatosis. Liver volume reduction plateaus 1-month post-bariatric surgery, but PDFF continues to decrease. LSG and LRYGB did not differ in efficacy for inducing regression of hepatosteatosis.

Indexed as

Gastric BypassAdultFemaleHumansLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseObesity, MorbidOrgan SizeProspective StudiesTreatment OutcomeBariatric surgeryGastric bypassLiver volumeNAFLDSleeve gastrectomy

Identifiers

PMID29218660
PMCPMC6690434
OpenAlexW2774597438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.