Evidence map›Paper›PMID 29218486›Full record

ArticleJournal of biomolecular NMR2018

Interaction study between HCV NS5A-D2 and NS5B using

Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Xavier Hanoulle

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biomolecular NMR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Analytical chemistry · 2026
    Article
  3. 2'-Frontiers in molecular biosciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marie DujardinUniversité de Lille, CNRS, UMR 8576 - UGSF, 59000, Lille, France.
François-Xavier CantrelleUniversité de Lille, CNRS, UMR 8576 - UGSF, 59000, Lille, France.
Guy LippensLISBP, Université de Toulouse, CNRS, INRA, INSA, UPS 135 avenue de Rangueil, 31077, Toulouse, France.
Xavier HanoulleUniversité de Lille, CNRS, UMR 8576 - UGSF, 59000, Lille, France. Xavier.hanoulle@univ-lille1.fr.ORCID 0000-0002-3755-2680
Centre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-11-JSV8-005Agence Nationale de Recherches sur le Sida et les Hepatites Virales A02014-2
6 · The paper itself

Abstract

The non structural protein 5A (NS5A) regulates the replication of the hepatitis C viral RNA through a direct molecular interaction of its domain 2 (NS5A-D2) with the RNA dependent RNA polymerase NS5B. Because of conflicting data in the literature, we study here this molecular interaction using fluorinated versions of the NS5A-D2 protein derived from the JFH1 Hepatitis C Virus strain. Two methods to prepare fluorine-labelled NS5A-D2 involving the biosynthetic incorporation of a

Indexed as

FluorineFluorine-19 Magnetic Resonance ImagingHepacivirusIsotope LabelingNuclear Magnetic Resonance, BiomolecularRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsFluorineNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseViral Nonstructural Proteins19F NMR spectroscopy19F protein labellingHCV NS5A-D2HCV NS5BProtein–protein interaction

Identifiers

PMID29218486
OpenAlexW2771426206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.