Evidence map›Paper›PMID 29218424›Full record

ArticleThe AAPS journal2017

Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration.

Laura L Boles Ponto, Susan Walsh, Jiangeng Huang, Christine Mundt, Katherine Thede-Reynolds, G Leonard Watkins, John Sunderland, Michael Acevedo, Maureen Donovan

Open access · greenAbstract read
In one paragraph

Article in The AAPS journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Olfactory Drug Delivery in Rodents: Deposition and Pharmacokinetics.ACS pharmacology & translational science · 2025
    Article
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Laura L Boles PontoDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. laura-ponto@uiowa.edu.
Susan WalshDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Jiangeng HuangCollege of Pharmacy, Division of Pharmaceutics and Translational Therapeutics, Iowa City, Iowa, USA.
Christine MundtDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Katherine Thede-ReynoldsDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
G Leonard WatkinsDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
John SunderlandDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Michael AcevedoDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Maureen DonovanCollege of Pharmacy, Division of Pharmaceutics and Translational Therapeutics, Iowa City, Iowa, USA.
University of Iowa · USUniversity of Iowa Hospitals and Clinics · USHuazhong University of Science and Technology · CNTranslational Therapeutics (United States) · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Bypassing the Blood-Brain Barrier:Modulation of Transporters in the Nasal MucosR01DC008374 · NIDCD · UNIVERSITY OF IOWA · PI DONOVAN, MAUREEN D · 2007 to 2011
$1.6M
NIDCD NIH HHS R01 DC008374
6 · The paper itself

Abstract

To illustrate the use of imaging to quantify the transfer of materials from the nasal cavity to other anatomical compartments, specifically, transfer to the brain using the thymidine analogue, [

Indexed as

Blood-Brain BarrierPositron-Emission TomographyAdministration, IntranasalAnimalsDideoxynucleosidesFluorodeoxyglucose F18Nasal CavityOlfactory BulbPermeabilityRatsRats, Sprague-DawleyalovudineDideoxynucleosidesFluorodeoxyglucose F18[18F]fluorodeoxyglucose (FDG)[18F]fluorothymidine (FLT)Nasal absorptionPreclinical pharmacokineticsSite-specific absorption pharmacoimaging

Identifiers

PMID29218424
PMCPMC5798226
OpenAlexW2774358136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.