ArticleExperimental brain research2018
Timing of cortical activation during spontaneous swallowing.
Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Trial
- Effects of Acupuncture Combined with Conventional Rehabilitation Training for Patients with Post-Stroke Dysphagia: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2025Trial
- Upward Effortful Pitch Glide as a Predictor of Pharyngeal Constriction in Individuals With Upper Versus Lower Motor Neuron Lesions.American journal of speech-language pathology · 2026Article
- Using Machine Learning for the Automated Segmentation and Detection of Swallows Obtained by Digital Cervical Auscultation in Preterm Neonates.Dysphagia · 2026Article
- Use of Transfer Learning for the Automated Segmentation and Detection of Swallows via Digital Cervical Auscultation in Children.Dysphagia · 2025Article
- Research advances in dysphagia animal models.Animal models and experimental medicine · 2025Review
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- Short-term cortical activation changes associated with postural compensation in swallowing.Experimental brain research · 2024Article
- Electroacupuncture improves swallowing function in a post-stroke dysphagia mouse model by activating the motor cortex inputs to the nucleus tractus solitarii through the parabrachial nuclei.Nature communications · 2023Article
- Cortical Activation of Swallowing Using fNIRS: A Proof of Concept Study with Healthy Adults.Dysphagia · 2022Article
- Can Swallowing Cerebral Neurophysiology Be Evaluated during Ecological Food Intake Conditions? A Systematic Literature Review.Journal of clinical medicine · 2022Review
- Comparing amplitudes of transcranial direct current stimulation (tDCS) to the sensorimotor cortex during swallowing.Experimental brain research · 2022Article
- Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2021Article
- Nocturnal swallowing augments arousal intensity and arousal tachycardia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saliva accumulation in the oropharynx generates an automatic pattern of swallowing in the brainstem in animals. Previous fMRI studies have found that spontaneous saliva and water swallows in humans evoked activation following swallow onset in both precentral motor and postcentral somatosensory cortical regions. Using event-related averaging of continuous functional near infrared spectroscopy (fNIRS), we examined cortical hemodynamic responses (HDR) from 5 s before to 35 s after spontaneous reflexive saliva swallow onset in the lateral postcentral somatosensory and precentral motor regions in both hemispheres in healthy volunteers. Three HDR changes from baseline were detected. First, the onset of HDR occurred 2 s before swallow onset in the left postcentral somatosensory area and 0.67 s before swallow onset in the right postcentral somatosensory area. Second, an early HDR peak amplitude occurred 3-4 s after swallow onset in all four regions. Z scores relative to baseline pre-swallow cortical activity levels averaged 20 and 22.7 s in the right and left somatosensory regions and 10 and 15.8 s in left and right motor areas, respectively. Finally, a late HDR peak occurring between 22 and 23 s after swallow onset in the somatosensory regions and 17-19 s in the motor areas likely resulted from esophageal peristalsis. Overall, cortical activation timing relative to swallow onsets showed activation began before the pharyngeal phase of swallowing in the somatosensory areas. This indicates that somatosensory triggering of swallowing occurs not only in the brainstem but also in the cortex for reflexive saliva swallowing in awake humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.